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Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials
(JACC: Heart Failure, 2018-08-01)
© 2018 American College of Cardiology Foundation The number of persons with heart
failure has continued to rise over the last several years. Approximately one-half
of those living with heart failure have heart failure with ...
Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.
(Cell host & microbe, 2018-06)
HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced
cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency.
Probable mutations occur at sites of frequent ...
Special Considerations in the Management of Diabetes in Women.
(Journal of women's health (2002), 2018-05-10)
Type 2 diabetes and prediabetes are heterogeneous diseases that directly affect over
115 million Americans. Considerable gender differences exist with regard to diabetes
risk factors, hormonal effects on glucose, ...
Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk.
(The Journal of nutrition, 2018-07)
Recent studies, primarily in non-Hispanic whites, suggest that dietary patterns have
distinct metabolomic signatures that may influence disease risk. However, evidence
in South Asians, a group with unique dietary patterns ...
A prospective comparison of a noninvasive cardiac output monitor versus esophageal doppler monitor for goal-directed fluid therapy in colorectal surgery patients
(Anesthesia and Analgesia, 2014-01-01)
Copyright © 2014 International Anesthesia Research Society. BACKGROUND: Goal-directed
fluid therapy (GDFT) is associated with improved outcomes after surgery. The esophageal
Doppler monitor (EDM) is widely used, but has ...
Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.
(Journal of the American Geriatrics Society, 2018-05-08)
To determine whether combinations of inflammatory markers are related to physical
function.secondary analysis of baseline of three observational studies of community-dwelling
older adults MEASUREMENTS: The baseline data ...
Investigating pathogen burden in relation to a cumulative deficits index in a representative sample of US adults.
(Epidemiology and infection, 2018-06-14)
Pathogen burden is a construct developed to assess the cumulative effects of multiple,
persistent pathogens on morbidity and mortality. Despite the likely biological wear
and tear on multiple body systems caused by persistent ...
LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
(Journal of thoracic oncology : official publication of the International Association
for the Study of Lung Cancer, 2014-06)
Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer,
and understanding the pathways and phenotypes altered as a consequence will aid the
development of targeted therapeutic strategies. Gene ...
Unexpected Cardiac MRI Findings in Patients Presenting to the Emergency Department for Possible Acute Coronary Syndrome.
(Critical pathways in cardiology, 2018-09)
Stress cardiac magnetic resonance imaging (CMR) has become increasingly used in patients
presenting to the emergency department (ED) with symptoms concerning for acute coronary
syndrome (ACS). We hypothesized that CMR detects ...
Acute Myeloid Leukemia After Olaparib Treatment in Metastatic Castration-Resistant Prostate Cancer.
(Clinical genitourinary cancer, 2017-12)