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Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival.
(European journal of cancer (Oxford, England : 1990), 2020-07-09)
BACKGROUND:Cutaneous melanoma (CM) is the most lethal type of skin cancers. Nicotinamide
adenine dinucleotide phosphate (NADPH) plays an important role in anabolic reactions
and tumorigenesis, but many genes are involved ...
Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
(Scientific reports, 2015-01)
Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway
may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1
and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) ...
Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma.
(Cancer Epidemiol Biomarkers Prev, 2015-07)
BACKGROUND: The Notch signaling pathway is constitutively activated in human cutaneous
melanoma to promote growth and aggressive metastatic potential of primary melanoma
cells. Therefore, genetic variants in Notch pathway ...
HPV16 antibodies as risk factors for oropharyngeal cancer and their association with tumor HPV and smoking status.
(Oral Oncol, 2015-07)
BACKGROUND: Antibodies (Abs) to the HPV16 proteome increase risk for HPV-associated
OPC (HPVOPC). The goal of this study was to investigate the association of a panel
of HPV16 Abs with risk for OPC as well as the association ...
Apoptotic variants as predictors of risk of oropharyngeal cancer recurrence after definitive radiotherapy.
(Int J Cancer, 2015-11-15)
Single nucleotide polymorphisms (SNPs) in the promoter region of FAS and FASLG may
alter their transcriptional activity. Thus, we determined the associations between
four FAS and FASLG promoter variants (FAS1377G>A, rs2234767; ...
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
(Tumour Biol, 2015-09)
The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of
apoptosis and the transformation and progression of malignant cells. Genetic variations
in KIF1B may contribute to risk of epithelial ovarian ...
Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk.
(Int J Cancer, 2015-10-15)
Genome-wide association studies (GWASs) have characterized 13 loci associated with
melanoma, which only account for a small part of melanoma risk. To identify new genes
with too small an effect to be detected individually ...
Genetic polymorphisms of PAI-1 and PAR-1 are associated with acute normal tissue toxicity in Chinese rectal cancer patients treated with pelvic radiotherapy.
(OncoTargets and therapy, 2015-01)
Plasminogen activator inhibitor type 1 (PAI-1) and protease-activated receptor-1 (PAR-1)
are crucial mediators of the intestinal microenvironment and are involved in radiation-induced
acute and chronic injury. To evaluate ...
The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.
(PloS one, 2013-01)
TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs)
in its miRNA binding sites could modulate functions of the miRNA-target genes and
thus risk of cancers. In this study, we investigated ...
TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy.
(Medicine, 2015-11)
Acute toxicity is the main dose-limiting factor in the chemoradiotherapy of rectal
cancer patients and depends on several pro-inflammatory factors, including interleukin-1
(IL-1), IL-6, and tumor necrosis factor-alpha (TNF-α). ...