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Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival. 

Li, Hong; Wang, Yanru; Liu, Hongliang; Shi, Qiong; Li, Hongyu; Wu, Wenting; Zhu, Dakai; ... (13 authors) (Oncotarget, 2017-09)
To investigate whether genetic variants of platelet-derived growth factor (PDGF) signaling pathway genes are associated with survival of cutaneous melanoma (CM) patients, we assessed associations of single-nucleotide ...
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The P38α rs3804451 Variant Predicts Chemotherapy Response and Survival of Patients with Non-Small Cell Lung Cancer Treated with Platinum-Based Chemotherapy. 

Jia, Ming; Xu, Yuan; Zhu, Meiling; Wang, Mengyun; Sun, Menghong; Qian, Ji; Chang, Jianhua; ... (8 authors) (Translational oncology, 2016-12)
The JNK and P38α pathways play an important role in the sensitivity and outcomes of chemotherapy. We hypothesize that functional single nucleotide polymorphisms (SNPs) of genes of these pathways modulate outcomes of patients ...
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The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population. 

Wu, Junlong; Wang, Meilin; Chen, Haitao; Xu, Jianfeng; Zhang, Guiming; Gu, Chengyuan; Ding, Qiang; ... (10 authors) (Frontiers in oncology, 2020-01)
Background: Seventeen loci have been found to be associated with bladder cancer risk by genome-wide association studies (GWAS) in European population. However, little is known about contribution of low-frequency and rare ...
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Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. 

Ransohoff, Katherine J; Wu, Wenting; Cho, Hyunje G; Chahal, Harvind C; Lin, Yuan; Dai, Hong-Ji; Amos, Christopher I; ... (13 authors) (Oncotarget, 2017-03)
Genome-wide association studies have identified 21 susceptibility loci associated with melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere maintenance, and DNA repair in melanoma risk. Here, ...
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Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx. 

Zhang, Yang; Sturgis, Erich M; Li, Yuncheng; Wei, Qingyi; Huang, Zhigang; Li, Guojun (Scientific reports, 2017-01-03)
Functional mouse double minute-2 (MDM2) promoter variants may alter MDM2 expression and thus affect radiotherapy response and prognosis of squamous cell carcinoma of oropharynx (SCCOP). Thus we assessed association of 2 ...
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Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival. 

Dai, Wei; Liu, Hongliang; Chen, Ka; Xu, Xinyuan; Qian, Danwen; Luo, Sheng; Amos, Christopher I; ... (12 authors) (Molecular carcinogenesis, 2020-06)
A few single-nucleotide polymorphisms (SNPs) have been identified to be associated with cutaneous melanoma (CM) survival through genome-wide association studies, but stringent multiple testing corrections required for the ...
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A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization. 

He, Min; Hu, Xin; Chen, Li; Cao, A-Yong; Yu, Ke-Da; Shi, Ting-Yan; Kuang, Xia-Ying; ... (15 authors) (Oncotarget, 2014-12)
XRCC4 plays a crucial role in the non-homologous end joining pathway that maintains genome stability. In this two-stage case-control study with 1,764 non-BRCA1/2 breast cancer patients and 1,623 cancer-free controls, we ...
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Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma. 

Jin, Lei; Sturgis, Erich M; Zhang, Yang; Huang, Zhigang; Song, Xicheng; Li, Chao; Wei, Qingyi; ... (8 authors) (Molecular cancer, 2013-07-19)
Tumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity, and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic variants may modulate individual susceptibility ...
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CASP7 variants modify susceptibility to cervical cancer in Chinese women. 

Shi, Ting-Yan; He, Jing; Wang, Meng-Yun; Zhu, Mei-Ling; Yu, Ke-Da; Shao, Zhi-Ming; Sun, Meng-Hong; ... (10 authors) (Scientific reports, 2015-01)
Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus contribute to cervical cancer risk. In this case-control study of 1,486 cervical cancer cases and 1,301 controls, we investigated associations ...
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Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck. 

Sun, Yan; Yu, Wenbin; Sturgis, Erich M; Peng, Wei; Lei, Dapeng; Wei, Qingyi; Song, Xicheng; ... (8 authors) (BMC cancer, 2016-02-08)
FAS/FASL promoter variants are considered in altering transcriptional activity of those genes and consequently alter regulation of cell death. However, no studies have investigated whether tumor sites contribute ...
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Wei, Qingyi (142)
Liu, Hongliang (57)Luo, Sheng (38)Amos, Christopher I (27)Liu, Zhensheng (26)Lee, Jeffrey E (24)Christiani, David C (23)Su, Li (22)Sturgis, Erich M (21)Li, Guojun (18)... View MoreDate Issued2020 - 2023 (32)2010 - 2019 (104)2005 - 2009 (6)TypeJournal article (142)SubjectHumans (86)Female (68)Middle Aged (68)Male (63)Polymorphism, Single Nucleotide (63)Aged (52)Adult (43)Genetic Predisposition to Disease (41)Genotype (40)Case-Control Studies (28)... View MoreAffiliation of Duke Author(s)Duke (142)Institutes and Centers (142)School of Medicine (142)Clinical Science Departments (135)Duke Cancer Institute (134)Basic Science Departments (131)Medicine (128)Medicine, Medical Oncology (128)Population Health Sciences (119)Biostatistics & Bioinformatics (46)... View More
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