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Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion.
(eLife, 2016-03-22)
In the absence of salient sensory cues to guide behavior, animals must still execute
sequences of motor actions in order to forage and explore. How such successive motor
actions are coordinated to form global locomotion ...
LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
(Journal of thoracic oncology : official publication of the International Association
for the Study of Lung Cancer, 2014-06)
Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer,
and understanding the pathways and phenotypes altered as a consequence will aid the
development of targeted therapeutic strategies. Gene ...
Mapping nonlinear receptive field structure in primate retina at single cone resolution.
(eLife, 2015-10-30)
The function of a neural circuit is shaped by the computations performed by its interneurons,
which in many cases are not easily accessible to experimental investigation. Here,
we elucidate the transformation of visual signals ...
Probing the folded state of fibronectin type III domains in stretched fibrils by measuring buried cysteine accessibility.
(The Journal of biological chemistry, 2011-07)
Fibronectin (FN) is an extracellular matrix protein that is assembled into fibrils
by cells during tissue morphogenesis and wound healing. FN matrix fibrils are highly
elastic, but the mechanism of elasticity has been debated: ...
Genome-wide identification of autosomal genes with allelic imbalance of chromatin state.
(PloS one, 2017-01)
In mammals, monoallelic gene expression can result from X-chromosome inactivation,
genomic imprinting, and random monoallelic expression (RMAE). Epigenetic regulation
of RMAE is not fully understood. Here we analyze allelic ...
29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome.
(PloS one, 2012-01)
Recent research supports the view that changes in gene regulation, as opposed to changes
in the genes themselves, play a significant role in morphological evolution. Gene
regulation is largely dependent on transcription ...
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.
(The Journal of clinical investigation, 2016-07)
Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause
of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous
humor outflow structures of the eye result in elevated ...
Behavioural and physiological limits to vision in mammals.
(Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017-04)
Human vision is exquisitely sensitive-a dark-adapted observer is capable of reliably
detecting the absorption of a few quanta of light. Such sensitivity requires that
the sensory receptors of the retina, rod photoreceptors, ...
Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.
(PloS one, 2012-01)
It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic
encephalopathy (HIE). Many women use some form of analgesia during childbirth and
some anesthetic agents have been shown to be neuroprotective ...
Role of NHERF and scaffolding proteins in proximal tubule transport.
(Urological research, 2010-08)
Eukaryotic cells coordinate specific responses to hormones and growth factors by spatial
and temporal organization of "signaling components." Through the formation of multiprotein
complexes, cells are able to generate "signaling ...