Molecular data have converged on a consensus about the genus-level phylogeny of extant platyrrhine monkeys, but for most extinct taxa and certainly for those older than the Pleistocene we must rely upon morphological evidence ...

Zebrafish were tested in an appetitive Pavlovian delayed conditioning task. After an intertrial interval of k*T s (k=11.25; T=8, 16 or 32 s), a small, translucent vertical pole was illuminated (CS) for T s. Food was presented ...

Zebrafish were tested in an appetitive Pavlovian delayed conditioning task. After an intertrial interval of k*T s (k=11.25; T=8, 16 or 32 s), a small, translucent vertical pole was illuminated (CS) for T s. Food was presented ...

Most protein phosphatases have little intrinsic substrate specificity, making selective pharmacological inhibition of specific dephosphorylation reactions a challenging problem. In a screen for small molecules that protect ...

Lipids, either endogenously synthesized or exogenous, have been linked to human cancer. Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP). We demonstrated that conditional ...

Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably succumb to their disease. Thus there remains a pressing need for preclinical testing of new drugs and drug combinations for late-stage ...

Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the prostate and oestrogen receptor (ER) α is required to mediate this response. Previous studies utilizing tissue recombination with seminal ...

Microglia are immune effector cells in the central nervous system (CNS) and their activation, migration and proliferation play crucial roles in brain injuries and diseases. We examined the role of intracellular ...