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Communication practices in physician decision-making for an unstable critically ill patient with end-stage cancer.
(J Palliat Med, 2010-08)
BACKGROUND: Shared decision-making has become the standard of care for most medical
treatments. However, little is known about physician communication practices in the
decision making for unstable critically ill patients ...
Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma.
(BMC Cancer, 2010-05-19)
BACKGROUND: Malignant glioma is a rare cancer with poor survival. The influence of
diet and antioxidant intake on glioma survival is not well understood. The current
study examines the association between antioxidant intake ...
Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.
(Cancer Biol Ther, 2010-01)
We have previously shown that treatment of prostate cancer and melanoma cells expressing
GRP78 on their cell surface with antibody directed against the COOH-terminal domain
of GRP78 upregulates and activates p53 causing ...
Detection of depression in low resource settings: validation of the Patient Health Questionnaire (PHQ-9) and cultural concepts of distress in Nepal.
(BMC Psychiatry, 2016-03-08)
BACKGROUND: Despite recognition of the burden of disease due to mood disorders in
low- and middle-income countries, there is a lack of consensus on best practices for
detecting depression. Self-report screening tools, such ...
The influence of hepatic function on prostate cancer outcomes after radical prostatectomy.
(Prostate Cancer Prostatic Dis, 2010-06)
Prostate growth is dependent on circulating androgens, which can be influenced by
hepatic function. Liver disease has been suggested to influence prostate cancer (CaP)
incidence. However, the effect of hepatic function on ...
Critical role of TNF-α in cerebral aneurysm formation and progression to rupture.
(J Neuroinflammation, 2014-04-16)
BACKGROUND: Alterations in TNF-α expression have been associated with cerebral aneurysms,
but a direct role in formation, progression, and rupture has not been established.
METHODS: Cerebral aneurysms were induced through ...
5-α reductase inhibitors and prostate cancer prevention: where do we turn now?
(BMC Med, 2011-09-15)
With the lifetime risk of being diagnosed with prostate cancer so great, an effective
chemopreventive agent could have a profound impact on the lives of men. Despite decades
of searching for such an agent, physicians still ...
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
(PLoS Genet, 2010-02-19)
To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes
susceptibility genes that increase the risk of type 2 diabetes (T2D) in a Han Chinese
population. A two-stage genome-wide association (GWA) ...
A novel mutation of the ACADM gene (c.145C>G) associated with the common c.985A>G mutation on the other ACADM allele causes mild MCAD deficiency: a case report.
(Orphanet J Rare Dis, 2010-10-05)
A female patient, with normal familial history, developed at the age of 30 months
an episode of diarrhoea, vomiting and lethargy which resolved spontaneously. At the
age of 3 years, the patient re-iterated vomiting, was ...
Small-bodied humans from Palau, Micronesia.
(PLoS One, 2008-03-12)
UNLABELLED: Newly discovered fossil assemblages of small bodied Homo sapiens from
Palau, Micronesia possess characters thought to be taxonomically primitive for the
genus Homo. BACKGROUND: Recent surface collection and test ...