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A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014-05)
Mechanisms of cerebellar motor learning are still poorly understood. The standard
Marr-Albus-Ito theory posits that learning involves plasticity at the parallel fiber
to Purkinje cell synapses under control of the climbing ...
Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors.
(Cell reports, 2016-04)
Numerous studies have shown that cerebellar function is related to the plasticity
at the synapses between parallel fibers and Purkinje cells. How specific input patterns
determine plasticity outcomes, as well as the biophysics ...
Characteristics of sequential activity in networks with temporally asymmetric Hebbian learning.
(Proceedings of the National Academy of Sciences of the United States of America, 2020-11-11)
Sequential activity has been observed in multiple neuronal circuits across species,
neural structures, and behaviors. It has been hypothesized that sequences could arise
from learning processes. However, it is still unclear ...
Inhibition stabilization is a widespread property of cortical networks.
(eLife, 2020-06-29)
Many cortical network models use recurrent coupling strong enough to require inhibition
for stabilization. Yet it has been experimentally unclear whether inhibition-stabilized
network (ISN) models describe cortical function ...
Acetylcholine Modulates Cerebellar Granule Cell Spiking by Regulating the Balance of Synaptic Excitation and Inhibition.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020-04)
Sensorimotor integration in the cerebellum is essential for refining motor output,
and the first stage of this processing occurs in the granule cell layer. Recent evidence
suggests that granule cell layer synaptic integration ...
Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx.
(Scientific reports, 2017-01-03)
Functional mouse double minute-2 (MDM2) promoter variants may alter MDM2 expression
and thus affect radiotherapy response and prognosis of squamous cell carcinoma of
oropharynx (SCCOP). Thus we assessed association of 2 ...
Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development.
(The Journal of experimental medicine, 2020-04)
In a forward genetic screen of N-ethyl-N-nitrosourea (ENU)-induced mutant mice for
aberrant immune function, we identified mice with a syndromic disorder marked by growth
retardation, diabetes, premature death, and severe ...
Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4.
(J Clin Invest, 2010-06)
Pulmonary fibrosis is a progressive, dysregulated response to injury culminating in
compromised lung function due to excess extracellular matrix production. The heparan
sulfate proteoglycan syndecan-4 is important in mediating ...
c-Myc is required for maintenance of glioma cancer stem cells.
(PLoS One, 2008)
BACKGROUND: Malignant gliomas rank among the most lethal cancers. Gliomas display
a striking cellular heterogeneity with a hierarchy of differentiation states. Recent
studies support the existence of cancer stem cells in ...
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
(PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus
aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential
phenotype are unknown. Using chromosome ...