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Quality control autophagy: a joint effort of ubiquitin, protein deacetylase and actin cytoskeleton.
(Autophagy, 2010-05)
Autophagy has been predominantly studied as a nonselective self-digestion process
that recycles macromolecules and produces energy in response to starvation. However,
autophagy independent of nutrient status has long been ...
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
(Autophagy, 2010-02)
VCP (VCP/p97) is a ubiquitously expressed member of the AAA(+)-ATPase family of chaperone-like
proteins that regulates numerous cellular processes including chromatin decondensation,
homotypic membrane fusion and ...
Characterization of topographical effects on macrophage behavior in a foreign body response model.
(Biomaterials, 2010-05)
Current strategies to limit macrophage adhesion, fusion and fibrous capsule formation
in the foreign body response have focused on modulating material surface properties.
We hypothesize that topography close to biological ...
Critical role of TNF-α in cerebral aneurysm formation and progression to rupture.
(J Neuroinflammation, 2014-04-16)
BACKGROUND: Alterations in TNF-α expression have been associated with cerebral aneurysms,
but a direct role in formation, progression, and rupture has not been established.
METHODS: Cerebral aneurysms were induced through ...
Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.
(PLoS One, 2015)
Addition of menthol to cigarettes may be associated with increased initiation of smoking.
The potential mechanisms underlying this association are not known. Menthol, likely
due to its effects on cold-sensing peripheral ...
Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice.
(PLoS One, 2010-08-17)
BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to result from stimulation
of immune responses against resident intestinal bacteria within a genetically susceptible
host. Mast cells may play a critical role ...
Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection.
(PLoS Pathog, 2010-03-12)
Natural killer (NK) cells play an essential role in innate immune control of poxviral
infections in vivo. However, the mechanism(s) underlying NK cell activation and function
in response to poxviruses remains poorly understood. ...
Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli.
(PLoS One, 2008-05-07)
Oxidative skeletal muscles are more resistant than glycolytic muscles to cachexia
caused by chronic heart failure and other chronic diseases. The molecular mechanism
for the protection associated with oxidative phenotype ...
Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection.
(PLoS One, 2015)
Although neuroanatomical tracing studies have defined the origin and targets of major
projection neurons (PN) of the central nervous system (CNS), there is much less information
about the circuits that influence these neurons. ...
Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage.
(Elife, 2013-04-30)
Dengue Virus (DENV), a flavivirus spread by mosquito vectors, can cause vascular leakage
and hemorrhaging. However, the processes that underlie increased vascular permeability
and pathological plasma leakage during viral ...