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LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
(Journal of thoracic oncology : official publication of the International Association
for the Study of Lung Cancer, 2014-06)
Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer,
and understanding the pathways and phenotypes altered as a consequence will aid the
development of targeted therapeutic strategies. Gene ...
Probing the folded state of fibronectin type III domains in stretched fibrils by measuring buried cysteine accessibility.
(The Journal of biological chemistry, 2011-07)
Fibronectin (FN) is an extracellular matrix protein that is assembled into fibrils
by cells during tissue morphogenesis and wound healing. FN matrix fibrils are highly
elastic, but the mechanism of elasticity has been debated: ...
Genome-wide identification of autosomal genes with allelic imbalance of chromatin state.
(PloS one, 2017-01)
In mammals, monoallelic gene expression can result from X-chromosome inactivation,
genomic imprinting, and random monoallelic expression (RMAE). Epigenetic regulation
of RMAE is not fully understood. Here we analyze allelic ...
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.
(The Journal of clinical investigation, 2016-07)
Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause
of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous
humor outflow structures of the eye result in elevated ...
Role of NHERF and scaffolding proteins in proximal tubule transport.
(Urological research, 2010-08)
Eukaryotic cells coordinate specific responses to hormones and growth factors by spatial
and temporal organization of "signaling components." Through the formation of multiprotein
complexes, cells are able to generate "signaling ...
A neural network-based method for spectral distortion correction in photon counting x-ray CT.
(Physics in medicine and biology, 2016-08)
Spectral CT using a photon counting x-ray detector (PCXD) shows great potential for
measuring material composition based on energy dependent x-ray attenuation. Spectral
CT is especially suited for imaging with K-edge contrast ...
Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2.
(Cancer research, 2008-10)
Black cohosh is an herbal extract that is often used as an alternative to estrogen-based
replacement therapies to treat hot flushes that frequently accompany the transition
to menopause. Although cancer-free women as well ...
Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.
(Science signaling, 2017-05-16)
Placental activation of the renin-angiotensin system (RAS) plays a key role in the
pathogenesis of preeclampsia. Reactive oxygen species (ROS) are thought to affect
placental angiogenesis, which is critical for preventing ...
The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum.
(Cell, 2014-09)
The unfolded protein response (UPR) is a stress response program that reprograms cellular
translation and gene expression in response to proteotoxic stress in the endoplasmic
reticulum (ER). One of the primary means by which ...
Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.
(Advances in experimental medicine and biology, 2017-01)
We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating
microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, flexible, tissue-like,
biocompatible hydrogel s that have ...