Now showing items 1-10 of 309
The genomic analysis of erythrocyte microRNA expression in sickle cell diseases.
(PLoS One, 2008-06-04)
BACKGROUND: Since mature erythrocytes are terminally differentiated cells without nuclei and organelles, it is commonly thought that they do not contain nucleic acids. In this study, we have re-examined this issue by analyzing ...
Serotonin transporter genotype modulates social reward and punishment in rhesus macaques
(PLoS ONE, 2009)
Background: Serotonin signaling influences social behavior in both human and nonhuman primates. In humans, variation upstream of the promoter region of the serotonin transporter gene (5-HTTLPR) has recently been shown to ...
Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development.
(PLoS One, 2008-05-07)
BACKGROUND: Myosin VIIA (MyoVIIA) is an unconventional myosin necessary for vertebrate audition -. Human auditory transduction occurs in sensory hair cells with a staircase-like arrangement of apical protrusions called ...
Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli.
(PLoS One, 2008-05-07)
Oxidative skeletal muscles are more resistant than glycolytic muscles to cachexia caused by chronic heart failure and other chronic diseases. The molecular mechanism for the protection associated with oxidative phenotype ...
Vanilloid receptor TRPV1-mediated phosphorylation of ERK in murine adjuvant arthritis
(Osteoarthritis and Cartilage, 2009-02)
Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain
(Experimental Neurology, 2009-12)
Reactions to discrimination, stigmatization, ostracism, and other forms of interpersonal rejection: a multimotive model.
(Psychol Rev, 2009-04)
This article describes a new model that provides a framework for understanding people's reactions to threats to social acceptance and belonging as they occur in the context of diverse phenomena such as rejection, discrimination, ...
Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3.
In the present study, two analogues containing N-Me-Gly (Sarcosine, Sar) were synthesized to further investigate the structural-activity relationships of orphanin FQ/nociceptin (OFQ/NC, NC). The replacement of Gly(2) or ...
Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice.
(Neurosci Lett, 2002-10-11)
This work was designed to observe the effects of nociceptin(13-17), one of the main metabolites of nociceptin (also termed orphanin FQ), in pain modulation at supraspinal level in mice. Intracerebroventricular (i.c.v.) ...