Now showing items 1-10 of 293
Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.
(Cell host & microbe, 2018-06)
HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency. Probable mutations occur at sites of frequent ...
CABG or PCI for Diabetic Patients With Left Ventricular Dysfunction: Closing in on the Truth?
(Journal of the American College of Cardiology, 2018-02)
Impaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block (vol 71, pg 306, 2018)
(JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018-03-20)
Sex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization: Results From the STICH Trial (Surgical Treatment for Ischemic Heart Failure).
Female sex is conventionally considered a risk factor for coronary artery bypass grafting (CABG) and has been included as a poor prognostic factor in multiple cardiac operative risk evaluation scores. We aimed to investigate ...
Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk.
(Proceedings of the National Academy of Sciences of the United States of America, 2013-11)
Achieving an AIDS-free generation will require elimination of postnatal transmission of HIV-1 while maintaining the nutritional and immunologic benefits of breastfeeding for infants in developing regions. Maternal/infant ...
Six-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy.
(Open heart, 2018-01)
In patients with ischaemic left ventricular dysfunction, coronary artery bypass surgery (CABG) may decrease mortality, but it is not known whether CABG improves functional capacity.To determine whether CABG compared with ...
A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor.
(Frontiers in oncology, 2018-01)
Olfactory receptor OR51E2, also known as a Prostate Specific G-Protein Receptor, is highly expressed in prostate cancer but its function is not well understood. Through in silico and in vitro analyses, we identified 24 agonists ...
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
(Nature communications, 2017-11-23)
A strategy for HIV-1 vaccine development is to define envelope (Env) evolution of broadly neutralizing antibodies (bnAbs) in infection and to recreate those events by vaccination. Here, we report host tolerance mechanisms ...
IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.
(Communications biology, 2018-01)
HIV continues to be a major global health issue. In spite of successful prevention interventions and treatment methods, the development of an HIV vaccine remains a major priority for the field and would be the optimal strategy ...
HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees.
(Journal of virology, 2018-04)
Induction of broadly cross-reactive antiviral humoral responses with the capacity to target globally diverse circulating strains is a key goal for HIV-1 immunogen design. A major gap in the field is the identification of ...