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    cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. 

    Bolanowski, MA; Caron, MG; Dixon, RA; Dohlman, HG; Francke, U; Frielle, T; Kobilka, BK; ... (10 authors) (Proc Natl Acad Sci U S A, 1987-01)
    We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor. The deduced amino acid sequence (413 residues) is that of a protein containing seven clusters of hydrophobic amino acids suggestive of ...
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    Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. 

    Caron, MG; Daniel, KW; Frielle, T; Lefkowitz, Robert J (Proc Natl Acad Sci U S A, 1988-12)
    The beta 1- and beta 2-adrenergic receptors are two structurally related, but pharmacologically distinguishable, receptor subtypes, both of which activate adenylyl cyclase in a catecholamine-dependent manner through the ...
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    Chromosomal organization of adrenergic receptor genes. 

    Caron, MG; Cotecchia, S; Francke, U; Frielle, T; Lefkowitz, Robert J; Xue, FY; Yang-Feng, TL; ... (8 authors) (Proc Natl Acad Sci U S A, 1990-02)
    The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone ...
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    Cloning of the cDNA for the human beta 1-adrenergic receptor. 

    Caron, MG; Collins, Sheila; Daniel, KW; Frielle, T; Kobilka, BK; Lefkowitz, Robert J (Proc Natl Acad Sci U S A, 1987-11)
    Screening of a human placenta lambda gt11 library has led to the isolation of the cDNA for the human beta 1-adrenergic receptor (beta 1AR). Used as the probe was the human genomic clone termed G-21. This clone, which contains ...
     

     

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    AuthorCaron, MG (4)
    Frielle, T (4)
    Lefkowitz, Robert J (4)
    Daniel, KW (2)Francke, U (2)Kobilka, BK (2)Yang-Feng, TL (2)Bolanowski, MA (1)Collins, Sheila (1)Cotecchia, S (1)... View MoreDate Issued1987 (2)1988 (1)1990 (1)TypeJournal article (4)SubjectDNA (4)
    Humans (4)
    Receptors, Adrenergic, beta (4)Amino Acid Sequence (3)Animals (3)Base Sequence (2)Chromosome Mapping (2)Cricetinae (2)Cricetulus (2)Hybrid Cells (2)... View MoreAffiliation of Duke Author(s)Basic Science Departments (4)Biochemistry (4)Cell Biology (4)
    Chemistry (4)
    Clinical Science Departments (4)
    Duke (4)Duke Cancer Institute (4)Duke Institute for Brain Sciences (4)Institutes and Centers (4)Institutes and Provost's Academic Units (4)... View More