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Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
(J Clin Invest, 1996-04-01)
To assess the effect of targeted myocardial beta-adrenergic receptor (AR) stimulation
on relaxation and phospholamban regulation, we studied the physiological and biochemical
alterations associated with overexpression of ...
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
(J Clin Invest, 1999-07)
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic
strategy for treatment of cardiovascular diseases such as heart failure (HF). Before
gene therapy approaches to alter cardiac function ...
Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.
(Proc Natl Acad Sci U S A, 1990-07)
Pharmacologic, biochemical, and genetic analyses have demonstrated the existence of
multiple alpha 2-adrenergic receptor (alpha 2AR) subtypes. We have cloned a human
alpha 2AR by using the polymerase chain reaction with ...
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
(Proc Natl Acad Sci U S A, 1994-04-26)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated
receptor substrates, such as the beta-adrenergic receptor, triggering events leading
to receptor desensitization. beta ARK activity is ...
Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.
(Proc Natl Acad Sci U S A, 1996-07-23)
Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases
(GRKs) constitute a family of serine/threonine kinases that play a major role in the
agonist-induced phosphorylation and desensitization ...
G proteins in medicine.
(N Engl J Med, 1995-01-19)
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
(Proc Natl Acad Sci U S A, 1998-07-21)
The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic
receptor and plays a role in adrenergic regulation of Na+/H+ exchange. NHERF contains
two PDZ domains, the first of which is required ...
Chromosomal organization of adrenergic receptor genes.
(Proc Natl Acad Sci U S A, 1990-02)
The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are
a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors
that mediate the physiological effects of the hormone ...
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
(Proc Natl Acad Sci U S A, 1995-08-29)
Phosphorylation of G-protein-coupled receptors plays an important role in regulating
their function. In this study the G-protein-coupled receptor phosphatase (GRP) capable
of dephosphorylating G-protein-coupled receptor ...