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Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.
(Rejuvenation Res, 2015-04)
The lack of evolutionary established mechanisms linking genes to age-related traits
makes the problem of genetic susceptibility to health span inherently complex. One
complicating factor is genetic trade-off. Here we focused ...
How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.
(Biogerontology, 2016-02)
Increasing proportions of elderly individuals in developed countries combined with
substantial increases in related medical expenditures make the improvement of the
health of the elderly a high priority today. If the process ...
Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction.
(Rejuvenation Res, 2010-02)
Multiple functions of the beta2-adrenergic receptor (ADRB2) and angiotensin-converting
enzyme (ACE) genes warrant studies of their associations with aging-related phenotypes.
We focus on multimarker analyses and analyses ...
Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.
(J Gerontol A Biol Sci Med Sci, 2013-07)
This study focuses on the participants of the Long Life Family Study to elucidate
whether biogenetic mechanisms underlying relationships among heritable complex phenotypes
in parents function in the same way for the same ...
Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.
(Biogerontology, 2016-02)
Complex diseases are major contributors to human mortality in old age. Paradoxically,
many genetic variants that have been associated with increased risks of such diseases
are found in genomes of long-lived people, and do ...
Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.
(Aging Cell, 2011-06)
Progress in unraveling the genetic origins of healthy aging is tempered, in part,
by a lack of replication of effects, which is often considered a signature of false-positive
findings. We convincingly demonstrate that the ...
Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.
(PLoS One, 2015)
Insights into genetic origin of diseases and related traits could substantially impact
strategies for improving human health. The results of genome-wide association studies
(GWAS) are often positioned as discoveries ...