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    Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. 

    Allen, LF; Caron, MG; King, K; Lefkowitz, Robert J; Lomasney, JW; Lorenz, W; Regan, JW; ... (8 authors) (Proc Natl Acad Sci U S A, 1990-07)
    Pharmacologic, biochemical, and genetic analyses have demonstrated the existence of multiple alpha 2-adrenergic receptor (alpha 2AR) subtypes. We have cloned a human alpha 2AR by using the polymerase chain reaction with ...
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    Chromosomal organization of adrenergic receptor genes. 

    Caron, MG; Cotecchia, S; Francke, U; Frielle, T; Lefkowitz, Robert J; Xue, FY; Yang-Feng, TL; ... (8 authors) (Proc Natl Acad Sci U S A, 1990-02)
    The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone ...
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    Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. 

    Bonin, H; Bouvier, M; Caron, MG; Hnatowich, M; Lefkowitz, Robert J; Valiquette, M (Proc Natl Acad Sci U S A, 1990-07)
    Chronic exposure of various cell types to adrenergic agonists leads to a decrease in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the receptor away from the cell surface as well as a down-regulation ...
     

     

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    AuthorCaron, MG (3)Lefkowitz, Robert J (3)Yang-Feng, TL (2)Allen, LF (1)Bonin, H (1)Bouvier, M (1)Cotecchia, S (1)Francke, U (1)Frielle, T (1)Hnatowich, M (1)... View MoreDate Issued
    1990 (3)
    TypeJournal article (3)SubjectAnimals (3)
    Humans (3)
    Amino Acid Sequence (2)Cell Line (2)Molecular Sequence Data (2)Receptors, Adrenergic, alpha (2)Receptors, Adrenergic, beta (2)Transfection (2)Adenylyl Cyclases (1)Base Sequence (1)... View MoreAffiliation of Duke Author(s)Basic Science Departments (3)Biochemistry (3)Cell Biology (3)Chemistry (3)Clinical Science Departments (3)Duke (3)Duke Cancer Institute (3)Duke Institute for Brain Sciences (3)
    Institutes and Centers (3)
    Institutes and Provost's Academic Units (3)... View More