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Now showing items 1-10 of 12
Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
(Proc Natl Acad Sci U S A, 1994-04-26)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated
receptor substrates, such as the beta-adrenergic receptor, triggering events leading
to receptor desensitization. beta ARK activity is ...
Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.
(Proc Natl Acad Sci U S A, 1996-07-23)
Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases
(GRKs) constitute a family of serine/threonine kinases that play a major role in the
agonist-induced phosphorylation and desensitization ...
G proteins in medicine.
(N Engl J Med, 1995-01-19)
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
(Proc Natl Acad Sci U S A, 1995-08-29)
Phosphorylation of G-protein-coupled receptors plays an important role in regulating
their function. In this study the G-protein-coupled receptor phosphatase (GRP) capable
of dephosphorylating G-protein-coupled receptor ...
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
(Circ Res, 1999-01-08)
-Transgenic mouse models have been developed to manipulate beta-adrenergic receptor
(betaAR) signal transduction. Although several of these models have altered betaAR
subtypes, the specific functional sequelae of betaAR ...
Mitogenic signaling via G protein-coupled receptors.
(Endocr Rev, 1996-12)
The third beta is not the charm.
(J Clin Invest, 1996-07-15)
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
(Proc Natl Acad Sci U S A, 1995-09-26)
The mechanism of mitogen-activated protein (MAP) kinase activation by pertussis toxin-sensitive
Gi-coupled receptors is known to involve the beta gamma subunits of heterotrimeric
G proteins (G beta gamma), p21ras activation, ...
An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.
(Proc Natl Acad Sci U S A, 1994-04-26)
Phosphorylation of GTP-binding-regulatory (G)-protein-coupled receptors by specific
G-protein-coupled receptor kinases (GRKs) is a major mechanism responsible for agonist-mediated
desensitization of signal transduction processes. ...