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Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium.
(Scientific reports, 2017-04-11)
The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events
mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway
are associated with lung cancer risk and survival. ...
Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.
(The Journal of investigative dermatology, 2015-02)
Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway
involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using
data derived from published genome-wide association ...
Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival.
(Carcinogenesis, 2018-07)
Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with
variation in outcomes only partially predicted by grade and stage. Additional tools
to distinguish indolent from aggressive disease are needed. ...
Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.
(Molecular carcinogenesis, 2018-01)
Metzincins are key molecules in the degradation of the extracellular matrix and play
an important role in cellular processes such as cell migration, adhesion, and cell
fusion of malignant tumors, including cutaneous melanoma ...
A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.
(PloS one, 2012-01-17)
The functional polymorphism (rs1800566) in the NQO1 gene, a 609C>T substitution, leading
to proline-to-serine amino-acid and enzyme activity changes, has been implicated in
cancer risk, but individually published studies ...
Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk.
(International journal of cancer, 2018-04)
The platelet-derived growth factor (PDGF) signaling pathway plays important roles
in development and progression of human cancers. In our study, we aimed to identify
genetic variants of the PDGF pathway genes associated ...
Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.
(Molecular carcinogenesis, 2018-06)
Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies
worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility.
In this analysis of 349 newly diagnosed SCCHN patients ...
Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study.
(Oncotarget, 2016-09)
The Notch signaling pathway has been shown to have biological significance and therapeutic
application in non-small cell lung cancer (NSCLC). We hypothesize that genetic variants
of genes in the Notch signaling pathway are ...
Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer.
(International journal of cancer, 2018-11)
The toll-like receptor (TLR) signaling pathway plays an important role in the innate
immune responses and antigen-specific acquired immunity. Aberrant activation of the
TLR pathway has a significant impact on carcinogenesis ...
Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.
(Molecular carcinogenesis, 2018-02)
The P38MAPK pathway participates in regulating cell cycle, inflammation, development,
cell death, cell differentiation, and tumorigenesis. Genetic variants of some genes
in the P38MAPK pathway are reportedly associated with ...