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Trade-offs between cancer and other diseases: do they exist and influence longevity?
(Rejuvenation Res, 2010-08)
Relationships between aging, disease risks, and longevity are not yet well understood.
For example, joint increases in cancer risk and total survival observed in many human
populations and some experimental aging studies ...
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.
(Rejuvenation Res, 2015-04)
The lack of evolutionary established mechanisms linking genes to age-related traits
makes the problem of genetic susceptibility to health span inherently complex. One
complicating factor is genetic trade-off. Here we focused ...
Trade-offs between cancer and other diseases: do they exist and influence longevity?
(Rejuvenation Res, 2010-08)
Relationships between aging, disease risks, and longevity are not yet well understood.
For example, joint increases in cancer risk and total survival observed in many human
populations and some experimental aging studies ...
Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.
(Aging Cell, 2011-06)
Progress in unraveling the genetic origins of healthy aging is tempered, in part,
by a lack of replication of effects, which is often considered a signature of false-positive
findings. We convincingly demonstrate that the ...
Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.
(Rejuvenation Res, 2013-02)
Decades of studies of candidate genes show their complex role in aging-related traits.
We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular
diseases (CVD) and cancer in the parental and offspring ...
Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.
(PLoS Genet, 2014-01)
Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven
uniqueness in humans and its prominent role in geriatrics and gerontology. We use
large samples of longitudinally followed ...