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Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan. 

Arbeev, Konstantin; Arbeeva, L; Christensen, Kaare; Culminskaya, IV; Kulminski, Alexander; Province, MA; Schupf, N; ... (10 authors) (PLoS Genet, 2014-01)
Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ...

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AuthorArbeev, Konstantin (1)
Arbeeva, L (1)
Christensen, Kaare (1)Culminskaya, IV (1)Kulminski, Alexander (1)Province, MA (1)Schupf, N (1)Stallard, Eric (1)Ukraintseva, Svetlana (1)
Yashin, Anatoli I (1)
Date Issued
2014 (1)
Type
Journal article (1)
SubjectAge Factors (1)Aged (1)Aged, 80 and over (1)Alleles (1)Apolipoprotein E4 (1)Cardiovascular Diseases (1)Female (1)Genotype (1)Heterozygote (1)Humans (1)... View MoreAffiliation of Duke Author(s)Center for Population Health & Aging (1)Duke (1)Duke Cancer Institute (1)Duke Population Research Center (1)Duke Population Research Institute (1)Institutes and Centers (1)Institutes and Provost's Academic Units (1)Sanford School of Public Policy (1)School of Medicine (1)Social Science Research Institute (1)... View More
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