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The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span.
(Phys Life Rev, 2012-06)
A better understanding of processes and mechanisms linking human aging with changes
in health status and survival requires methods capable of analyzing new data that
take into account knowledge about these processes accumulated ...
Recovery and survival from aging-associated diseases.
(Exp Gerontol, 2013-08)
OBJECTIVES: Considering disease incidence to be a main contributor to healthy lifespan
of the US elderly population may lead to erroneous conclusions when recovery/long-term
remission factors are underestimated. Using two ...
Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.
(Mech Ageing Dev, 2011-04)
Recent studies have reported that leukocyte telomere length (LTL) is longer in offspring
of older fathers. Longer telomeres might increase cancer risk. We examined the relation
of father's age at the birth of the offspring ...
Joint influence of small-effect genetic variants on human longevity.
(Aging (Albany NY), 2010-09)
The results of genome-wide association studies of complex traits, such as life span
or age at onset of chronic disease, suggest that such traits are typically affected
by a large number of small-effect alleles. Individually ...
Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival.
(Front Public Health, 2014)
Longitudinal data on aging, health, and longevity provide a wealth of information
to investigate different aspects of the processes of aging and development of diseases
leading to death. Statistical methods aimed at analyses ...
Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.
(Rejuvenation Res, 2016-06)
On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity
Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that
interactions between carrying FOXO1A-209 genotypes ...
Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.
(Biogerontology, 2016-11)
The apolipoprotein E (apoE) is a classic example of a gene exhibiting pleiotropism.
We examine potential pleiotropic associations of the apoE2 allele in three biodemographic
cohorts of long-living individuals, offspring, ...
Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency.
(Sci Rep, 2016-10-14)
Common strategy of genome-wide association studies (GWAS) relying on large samples
faces difficulties, which raise concerns that GWAS have exhausted their potential,
particularly for complex traits. Here, we examine the ...
Biodemographic Analyses of Longitudinal Data on Aging, Health, and Longevity: Recent Advances and Future Perspectives.
(Adv Geriatr, 2017-06-02)
Biodemography became one of the most innovative and fastest growing areas in demography.
This progress is fueled by the growing variability and amount of relevant data available
for analyses as well as by methodological ...