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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.
(Psychiatry Res, 2013-04-30)
Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk
for suicidality, depression, and functional impairment. We thus conducted a small
(N=12) pilot randomized controlled trial (RCT) with paroxetine ...
Effects of chronic mild traumatic brain injury on white matter integrity in iraq and afghanistan war veterans
(Human Brain Mapping, 2013-11-01)
Mild traumatic brain injury (TBI) is a common source of morbidity from the wars in
Iraq and Afghanistan. With no overt lesions on structural MRI, diagnosis of chronic
mild TBI in military veterans relies on obtaining an ...
Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.
(J ECT, 2014-06)
For many patients with neuropsychiatric illnesses, standard psychiatric treatments
with mono or combination pharmacotherapy, psychotherapy, and transcranial magnetic
stimulation are ineffective. For these patients ...
Implementation and randomized controlled trial evaluation of universal postnatal nurse home visiting.
(Am J Public Health, 2014-02)
OBJECTIVES: We evaluated whether a brief, universal, postnatal nurse home-visiting
intervention can be implemented with high penetration and fidelity, prevent emergency
health care services, and promote positive parenting ...
Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya.
(PLoS One, 2017)
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular
disease burden. The clinical profile and outcomes of AF patients with valvular heart
diseases in sub-Saharan Africa (SSA) have not ...
Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques.
(Mol Ther, 2016-11)
The design of an effective HIV-1 vaccine remains a major challenge. Several vaccine
strategies based on viral vectors have been evaluated in preclinical and clinical
trials, with largely disappointing results. Integrase ...
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...
Amygdala-prefrontal cortex functional connectivity during threat-induced anxiety and goal distraction.
(Biol Psychiatry, 2015-02-15)
BACKGROUND: Anxiety produced by environmental threats can impair goal-directed processing
and is associated with a range of psychiatric disorders, particularly when aversive
events occur unpredictably. The prefrontal cortex ...