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Vaccine-induced memory CD8+ T cells provide clinical benefit in HER2 expressing breast cancer: a mouse to human translational study.
(Clinical cancer research : an official journal of the American Association for Cancer
Research, 2019-01-11)
PURPOSE:Immune-based therapy for metastatic breast cancer has had limited success,
particularly in molecular subtypes with low somatic mutations rates. Strategies to
augment T cell infiltration of tumors include vaccines ...
The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.
(Journal of the American Geriatrics Society, 2019-01-23)
BACKGROUND/OBJECTIVES:Every year, up to 40% of the more than 16 million older Americans
who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD)
or delirium. Each of these distinct syndromes is associated ...
Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children.
(International journal of environmental research and public health, 2019-02-25)
This study examines pre-pregnancy Body Mass Index (BMI) and gestational weight gain
(GWG) in relation to early childhood Attention Deficit Hyperactivity Disorder (ADHD)
symptoms and related executive self-regulation behaviors. ...
Enhancing activation in the right temporoparietal junction using theta-burst stimulation: Disambiguating between two hypotheses of top-down control of behavioral mimicry.
(PloS one, 2019-01-25)
Whereas previous research has focused on the role of the rTPJ when consciously inhibiting
mimicry, we test the role of the rTPJ on mimicry within a social interaction, during
which mimicking occurs nonconsciously. We wanted ...
Putting virtues in context: engaging the VIA classification of character strengths in caregiving for orphans and vulnerable children across cultures
(Journal of Positive Psychology, 2019-01-01)
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. The VIA Classification
of Character Strengths has broken important ground for measuring character strengths
across cultures. Because the VIA Classification ...
TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019-06)
Temporal lobe epilepsy (TLE) is a common and commonly devastating form of human epilepsy
for which only symptomatic therapy is available. One cause of TLE is an episode of
de novo prolonged seizures [status epilepticus (SE)]. ...
Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.
(Anesthesia and analgesia, 2019-05-03)
Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte
influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal
fluid (CSF) samples collected before ...
Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects.
(Scientific reports, 2019-06-18)
Meniscal tears have a poor healing capacity, and damage to the meniscus is associated
with significant pain, disability, and progressive degenerative changes in the knee
joint that lead to osteoarthritis. Therefore, strategies ...
State-level prevalence, health service use, and spending vary widely among Medicare beneficiaries with Parkinson disease.
(NPJ Parkinson's disease, 2019-01-24)
State-level variations in disease, healthcare utilization, and spending influence
healthcare planning at federal and state levels and should be examined to understand
national disparities in health outcomes. This descriptive ...
Commentary on Winhusen et al. (2019): Substance use disorders, chronic diseases, and electronic health records-a paradigm for screening and intervention.
(Addiction (Abingdon, England), 2019-08)