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Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.
(Kidney Int, 2014-12)
Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes,
including inherited genetic defects, with significant proteinuria being the predominant
clinical finding at presentation. Mutations in ...
Long-term dynamics of death rates of emphysema, asthma, and pneumonia and improving air quality.
(Int J Chron Obstruct Pulmon Dis, 2014)
BACKGROUND: The respiratory tract is a major target of exposure to air pollutants,
and respiratory diseases are associated with both short- and long-term exposures.
We hypothesized that improved air quality in North Carolina ...
Use of Salvia divinorum in a nationally representative sample.
(The American journal of drug and alcohol abuse, 2012-01)
Salvia divinorum has known hallucinogenic effects and is legal in most parts of the
United States. Given that this psychoactive substance has a potential of misuse and
abuse, further data regarding the clinical and psychosocial ...
Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies.
(Epidemics, 2015-06)
The effectiveness of vaccinating males against the human papillomavirus (HPV) remains
a controversial subject. Many existing studies conclude that increasing female coverage
is more effective than diverting resources into ...
Young caregivers in the end-of-life setting: a population-based profile of an emerging group.
(J Palliat Med, 2010-10)
PURPOSE: Little is known about young caregivers of people with advanced life-limiting
illness. Better understanding of the needs and characteristics of these young caregivers
can inform development of palliative care and ...
A neural biomarker of psychological vulnerability to future life stress.
(Neuron, 2015-02-04)
We all experience a host of common life stressors such as the death of a family member,
medical illness, and financial uncertainty. While most of us are resilient to such
stressors, continuing to function normally, for a ...
Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.
(PLoS Genet, 2011-08)
Exposure to influenza viruses is necessary, but not sufficient, for healthy human
hosts to develop symptomatic illness. The host response is an important determinant
of disease progression. In order to delineate host molecular ...
Antibiotic overuse for acute respiratory tract infections in Sri Lanka: a qualitative study of outpatients and their physicians.
(BMC Fam Pract, 2018-03-01)
BACKGROUND: Acute respiratory tract infections (ARTIs) are a common reason for antibiotic
overuse worldwide. We previously showed that over 80% of outpatients presenting to
a tertiary care hospital in Sri Lanka ...
Chikungunya as a cause of acute febrile illness in southern Sri Lanka.
(PLoS One, 2013)
BACKGROUND: Chikungunya virus (CHIKV) re-emerged in Sri Lanka in late 2006 after a
40-year hiatus. We sought to identify and characterize acute chikungunya infection
(CHIK) in patients presenting with acute undifferentiated ...
Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine.
(Drug Des Devel Ther, 2013)
OBJECTIVE: MAP0004 is an investigational product which delivers dihydroergotamine
(DHE) through the lung via a breath-synchronized metered dose inhaler. The objective
of this study was to compare the acute effects of orally ...