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The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for nonmalignant diseases.
(Blood, 2019-02)
Despite improvements, mortality after allogeneic hematopoietic cell transplantation
(HCT) for nonmalignant diseases remains a significant problem. We evaluated whether
pre-HCT conditions defined by the HCT Comorbidity Index ...
Survival and Functional Outcomes in Boys with Cerebral Adrenoleukodystrophy with and without Hematopoietic Stem Cell Transplantation.
(Biology of blood and marrow transplantation : journal of the American Society for
Blood and Marrow Transplantation, 2019-03)
Cerebral adrenoleukodystrophy (CALD) is a rapidly progressing, often fatal neurodegenerative
disease caused by mutations in the ABCD1 gene, resulting in deficiency of ALD protein.
Clinical benefit has been reported following ...
Phase I/II Study of Stem-Cell Transplantation Using a Single Cord Blood Unit Expanded Ex Vivo With Nicotinamide.
(Journal of clinical oncology : official journal of the American Society of Clinical
Oncology, 2019-02)
<h4>Purpose</h4>Increasing the number of hematopoietic stem and progenitor cells within
an umbilical cord blood (UCB) graft shortens the time to hematopoietic recovery after
UCB transplantation. In this study, we assessed ...
Factors Associated with Long-Term Risk of Relapse after Unrelated Cord Blood Transplantation in Children with Acute Lymphoblastic Leukemia in Remission.
(Biology of blood and marrow transplantation : journal of the American Society for
Blood and Marrow Transplantation, 2017-08)
For pediatric patients with acute lymphoblastic leukemia (ALL), relapse is an important
cause of treatment failure after unrelated cord blood transplant (UCBT). Compared
with other donor sources, relapse is similar or even ...
Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial.
(Biology of blood and marrow transplantation : journal of the American Society for
Blood and Marrow Transplantation, 2010-07)
Therapeutic options for severe hepatic veno-occlusive disease (VOD) are limited and
outcomes are dismal, but early phase I/II studies have suggested promising activity
and acceptable toxicity using the novel polydisperse ...
Pulmonary Complications in Pediatric and Adolescent Patients Following Allogeneic Hematopoietic Cell Transplantation.
(Biology of blood and marrow transplantation : journal of the American Society for
Blood and Marrow Transplantation, 2019-10)
Pulmonary complications after hematopoietic cell transplantation (HCT) can lead to
significant morbidity and mortality. Limited evaluation of the true incidence of these
complications in children and subsequent outcomes ...
The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia.
(Blood advances, 2019-04)
When hematopoietic stem cell transplant (HSCT) is necessary for children with acute
myeloid leukemia (AML), there remains debate about the best stem cell source. Post-HSCT
relapse is a common cause of mortality, and complications ...
Voriconazole pharmacokinetics following HSCT: results from the BMT CTN 0101 trial.
(The Journal of antimicrobial chemotherapy, 2016-08)
<h4>Background</h4>Voriconazole is a first-line agent for the prevention and treatment
of a number of invasive fungal diseases. Relatively little is known about the relationship
between drug exposure and the prevention of ...
Outcome of transplantation for acute myelogenous leukemia in children with Down syndrome.
(Biology of blood and marrow transplantation : journal of the American Society for
Blood and Marrow Transplantation, 2013-06)
Data on outcomes of allogeneic transplantation in children with Down syndrome and
acute myelogenous leukemia (DS-AML) are scarce and conflicting. Early reports stress
treatment-related mortality as the main barrier; a recent ...
NCI, NHLBI first international consensus conference on late effects after pediatric hematopoietic cell transplantation: state of the science, future directions.
(Biology of blood and marrow transplantation : journal of the American Society for
Blood and Marrow Transplantation, 2011-10)