Now showing items 1-10 of 635
Quality control autophagy: a joint effort of ubiquitin, protein deacetylase and actin cytoskeleton.
Autophagy has been predominantly studied as a nonselective self-digestion process that recycles macromolecules and produces energy in response to starvation. However, autophagy independent of nutrient status has long been ...
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
VCP (VCP/p97) is a ubiquitously expressed member of the AAA(+)-ATPase family of chaperone-like proteins that regulates numerous cellular processes including chromatin decondensation, homotypic membrane fusion and ...
The genomic analysis of erythrocyte microRNA expression in sickle cell diseases.
(PLoS One, 2008-06-04)
BACKGROUND: Since mature erythrocytes are terminally differentiated cells without nuclei and organelles, it is commonly thought that they do not contain nucleic acids. In this study, we have re-examined this issue by analyzing ...
Kinesins at a glance.
(J Cell Sci, 2010-10-15)
Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice.
(PLoS One, 2010-08-17)
BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to result from stimulation of immune responses against resident intestinal bacteria within a genetically susceptible host. Mast cells may play a critical role ...
Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development.
(PLoS One, 2008-05-07)
BACKGROUND: Myosin VIIA (MyoVIIA) is an unconventional myosin necessary for vertebrate audition -. Human auditory transduction occurs in sensory hair cells with a staircase-like arrangement of apical protrusions called ...
Computational Methods for RNA Structure Validation and Improvement.
(Methods Enzymol, 2015)
With increasing recognition of the roles RNA molecules and RNA/protein complexes play in an unexpected variety of biological processes, understanding of RNA structure-function relationships is of high current importance. ...
Reactions to discrimination, stigmatization, ostracism, and other forms of interpersonal rejection: a multimotive model.
(Psychol Rev, 2009-04)
This article describes a new model that provides a framework for understanding people's reactions to threats to social acceptance and belonging as they occur in the context of diverse phenomena such as rejection, discrimination, ...
Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease.
(PLoS Biol, 2010-01-19)
Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding defect inherent to poly-glutamine (polyQ) proteins. Given the ...
The dopamine metabolite 3-methoxytyramine is a neuromodulator.
(PLoS One, 2010-10-18)
Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved in multiple physiological functions including movement control. Here we report that the major extracellular metabolite of dopamine, ...