Now showing items 1-10 of 587
Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma.
(BMC Cancer, 2010-05-19)
BACKGROUND: Malignant glioma is a rare cancer with poor survival. The influence of diet and antioxidant intake on glioma survival is not well understood. The current study examines the association between antioxidant intake ...
Quality control autophagy: a joint effort of ubiquitin, protein deacetylase and actin cytoskeleton.
Autophagy has been predominantly studied as a nonselective self-digestion process that recycles macromolecules and produces energy in response to starvation. However, autophagy independent of nutrient status has long been ...
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
VCP (VCP/p97) is a ubiquitously expressed member of the AAA(+)-ATPase family of chaperone-like proteins that regulates numerous cellular processes including chromatin decondensation, homotypic membrane fusion and ...
The genomic analysis of erythrocyte microRNA expression in sickle cell diseases.
(PLoS One, 2008-06-04)
BACKGROUND: Since mature erythrocytes are terminally differentiated cells without nuclei and organelles, it is commonly thought that they do not contain nucleic acids. In this study, we have re-examined this issue by analyzing ...
Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice.
(PLoS One, 2010-08-17)
BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to result from stimulation of immune responses against resident intestinal bacteria within a genetically susceptible host. Mast cells may play a critical role ...
Thromboembolism and bleeding in bladder cancer.
(Oncology (Williston Park), 2014-10)
Bladder cancer is a unique disease process in that clinically significant hemorrhage can occur simultaneously with equally significant aberrant clotting. With hematuria the key presenting symptom of bladder cancer, hemorrhage ...
Pilot randomized trial on mindfulness training for smokers in young adult binge drinkers.
(BMC Complement Altern Med, 2013-09-03)
BACKGROUND: We report results of a pilot study designed to test a novel smoking cessation intervention, Mindfulness Training for Smokers (MTS), in smokers age 18-29 years with regular episodes of binge drinking. Mindfulness ...
Computational Methods for RNA Structure Validation and Improvement.
(Methods Enzymol, 2015)
With increasing recognition of the roles RNA molecules and RNA/protein complexes play in an unexpected variety of biological processes, understanding of RNA structure-function relationships is of high current importance. ...
Refusal in testicular cancer patients: implications for surveillance.
(Br J Cancer, 1992-05)
Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease.
(PLoS Biol, 2010-01-19)
Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding defect inherent to poly-glutamine (polyQ) proteins. Given the ...