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Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.
Temporomandibular joint disorder (TMJD) is known for its mastication-associated pain. TMJD is medically relevant because of its prevalence, severity, chronicity, the therapy-refractoriness of its pain, and its largely elusive ...
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.
(Proc Natl Acad Sci U S A, 2013-08-20)
At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin ...
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.
Detection of external irritants by head nociceptor neurons has deep evolutionary roots. Irritant-induced aversive behavior is a popular pain model in laboratory animals. It is used widely in the formalin model, where formaldehyde ...
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
(Proc Natl Acad Sci U S A, 2014-11-25)
Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities ...