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Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.

Arbeev, Konstantin; Culminskaya, IV; Kulminski, Alexander; Province, MA; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Rejuvenation Res, 2015-04)

The lack of evolutionary established mechanisms linking genes to age-related traits makes the problem of genetic susceptibility to health span inherently complex. One complicating factor is genetic trade-off. Here we focused ...

How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.

Akushevich, Igor; Arbeev, Konstantin; Arbeeva, LS; Culminskaya, IV; Kovtun, Mikhail; Kulminski, Alexander; Li, M; ... (12 authors) (Biogerontology, 2016-02)

Increasing proportions of elderly individuals in developed countries combined with substantial increases in related medical expenditures make the improvement of the health of the elderly a high priority today. If the process ...

Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.

Akushevich, Igor; Arbeev, Konstantin; Joshi, G; Kulminski, Alexander; Land, Kenneth C; Stallard, Eric; Ukraintseva, Svetlana; ... (9 authors) (Biogerontology, 2016-02)

Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do ...

Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.

Arbeev, Konstantin; Arbeeva, L; Christensen, Kaare; Culminskaya, IV; Kulminski, Alexander; Province, MA; Schupf, N; ... (10 authors) (PLoS Genet, 2014-01)

Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ...