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A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.
(Psychiatry Res, 2013-04-30)
Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk
for suicidality, depression, and functional impairment. We thus conducted a small
(N=12) pilot randomized controlled trial (RCT) with paroxetine ...
Implementation and randomized controlled trial evaluation of universal postnatal nurse home visiting.
(Am J Public Health, 2014-02)
OBJECTIVES: We evaluated whether a brief, universal, postnatal nurse home-visiting
intervention can be implemented with high penetration and fidelity, prevent emergency
health care services, and promote positive parenting ...
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...
Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder.
(Transl Psychiatry, 2015-12-15)
Fear conditioning is an established model for investigating posttraumatic stress disorder
(PTSD). However, symptom triggers may vaguely resemble the initial traumatic event,
differing on a variety of sensory and affective ...
Cardiorespiratory fitness and cognitive function in midlife: neuroprotection or neuroselection?
(Ann Neurol, 2015-04)
OBJECTIVE: A study was undertaken to determine whether better cognitive functioning
at midlife among more physically fit individuals reflects neuroprotection, by which
fitness protects against age-related cognitive decline, ...
Less wiring, more firing: low-performing older adults compensate for impaired white matter with greater neural activity.
(Cereb Cortex, 2015-04)
The reliable neuroimaging finding that older adults often show greater activity (over-recruitment)
than younger adults is typically attributed to compensation. Yet, the neural mechanisms
of over-recruitment in older adults ...
Cross-hemispheric collaboration and segregation associated with task difficulty as revealed by structural and functional connectivity.
(J Neurosci, 2015-05-27)
Although it is known that brain regions in one hemisphere may interact very closely
with their corresponding contralateral regions (collaboration) or operate relatively
independent of them (segregation), the specific brain ...
Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.
(Pain Med, 2016-01)
BACKGROUND AND OBJECTIVES: Pain symptoms are common among Iraq/Afghanistan-era veterans,
many of whom continue to experience persistent pain symptoms despite multiple pharmacological
interventions. Preclinical data suggest ...
Is chronic asthma associated with shorter leukocyte telomere length at midlife?
(Am J Respir Crit Care Med, 2014-08-15)
RATIONALE: Asthma is prospectively associated with age-related chronic diseases and
mortality, suggesting the hypothesis that asthma may relate to a general, multisystem
phenotype of accelerated aging. OBJECTIVES: To test ...
Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.
(Nat Neurosci, 2014-08)
Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating
nervous tissue, yet its mechanisms of effect are poorly understood. Here we report
new methods for studying the influence of TMS ...