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Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes.

Liu, Zhensheng; Wei, Qingyi; Yu, Hongping; Zhao, Hui; Wang, Li-E; Li, Donghui (PloS one, 2012-01)

In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral lymphocytes have been shown to be a phenotypic biomarker of individual's DNA repair phenotype that is associated with cancer risk. In ...

Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.

Liu, Zhensheng; Wei, Qingyi; Guan, Xiaoxiang; Yin, Ming; Zhao, Hui; Wang, Li-E; Yuan, Xianglin; ... (10 authors) (BMC cancer, 2010-08-16)

Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms may affect survival outcomes among locally advanced ...

Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.

Liu, Zhensheng; Wei, Qingyi; Yu, Hongping; Huang, Yu-Jing; Yin, Ming; Wang, Li-E (PloS one, 2012-01)

Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks. Single nucleotide ...

Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.

Liu, Zhensheng; Wei, Qingyi; Ma, Hongxia; Wang, Li-E; Sturgis, Erich M (BMC cancer, 2011-06-20)

Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the head and neck ...

Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.

Liu, Zhensheng; Wei, Qingyi; Han, Chan H; Huang, Yu-Jing; Lu, Karen H; Mills, Gordon B; Wang, Li-E (Journal of experimental & clinical cancer research : CR, 2011-01-07)

SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various cancers, including ...

Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.

Liu, Zhensheng; Wei, Qingyi; Yin, Jieyun; Liu, Hongliang; Wang, Li-E; Chen, Wei V; Zhu, Dakai; ... (10 authors) (The Journal of investigative dermatology, 2015-02)

Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived from published genome-wide association ...

Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.

Liu, Zhensheng; Wei, Qingyi; Zhou, Ziyuan; Sturgis, Erich M; Wang, Li-E; Li, Guojun (BMC cancer, 2012-05)

The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F ...

Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.

Wei, Qingyi; Liu, Zhensheng; Guan, Xiaoxiang; Wang, Li-E; Sturgis, Erich M (Journal of cellular and molecular medicine, 2013-07)

Recently, several studies have investigated the association between a newly reported rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer risk, but generated inconsistent findings. The present ...

TGFβ1 Polymorphisms Predict Distant Metastasis-Free Survival in Patients with Inoperable Non-Small-Cell Lung Cancer after Definitive Radiotherapy.

Wei, Qingyi; Liu, Zhensheng; Yuan, Xianglin; Komaki, Ritsuko; Yang, Ju; Tucker, Susan L; Xu, Ting; ... (11 authors) (PloS one, 2013-01)

Transforming growth factor (TGF) -β1 signaling is involved in cancer-cell metastasis. We investigated whether single nucleotide polymorphisms (SNPs) at TGFβ1 were associated with overall survival (OS) and distant metastasis-free ...

Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy.

Liu, Zhensheng; Wei, Qingyi; Wen, Juyi; Liu, Hongliang; Wang, Lili; Wang, Xiaomeng; Gu, Ning; ... (11 authors) (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018-05)

INTRODUCTION:Autophagy not only plays an important role in the progression of cancer but is also involved in tissue inflammatory response. However, few published studies have investigated associations between functional ...