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Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer. 

Wang, Qiming; Liu, Hongliang; Xiong, Huihua; Liu, Zhensheng; Wang, Li-E; Qian, Ji; Muddasani, Ramya; ... (11 authors) (Mol Carcinog, 2015-06)
CD133 is one of the most common stem cell markers, and functional single nucleotide polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk and patient survival. We hypothesized that potentially ...
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A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population. 

Zhou, Keke; Hu, Dezhi; Lu, Juan; Fan, Weiwei; Liu, Hongliang; Chen, Hongyan; Chen, Gong; ... (12 authors) (BMC cancer, 2011-01)
BACKGROUND: The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1 (APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1 promoter -141T/G variant (rs1760944) has been reported ...
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Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk. 

Yang, Wenjun; Liu, Hongliang; Duan, Bensong; Xu, Xinyuan; Carmody, Dennis; Luo, Sheng; Walsh, Kyle M; ... (11 authors) (Cancer science, 2019-06)
Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles ...
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A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis. 

Yu, Hongping; Liu, Hongliang; Wang, Li-E; Wei, Qingyi (PloS one, 2012-01-17)
The functional polymorphism (rs1800566) in the NQO1 gene, a 609C>T substitution, leading to proline-to-serine amino-acid and enzyme activity changes, has been implicated in cancer risk, but individually published studies ...
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Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival. 

Freedman, Jennifer A; Wang, Yanru; Li, Xuechan; Liu, Hongliang; Moorman, Patricia G; George, Daniel J; Lee, Norman H; ... (10 authors) (Carcinogenesis, 2018-07)
Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with variation in outcomes only partially predicted by grade and stage. Additional tools to distinguish indolent from aggressive disease are needed. ...
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Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer. 

Feng, Yun; Wang, Yanru; Liu, Hongliang; Liu, Zhensheng; Mills, Coleman; Owzar, Kouros; Xie, Jichun; ... (25 authors) (Molecular carcinogenesis, 2018-02)
The P38MAPK pathway participates in regulating cell cycle, inflammation, development, cell death, cell differentiation, and tumorigenesis. Genetic variants of some genes in the P38MAPK pathway are reportedly associated with ...
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Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk. 

Duan, Bensong; Hu, Jiangfeng; Liu, Hongliang; Wang, Yanru; Li, Hongyu; Liu, Shun; Xie, Jichun; ... (12 authors) (International journal of cancer, 2018-04)
The platelet-derived growth factor (PDGF) signaling pathway plays important roles in development and progression of human cancers. In our study, we aimed to identify genetic variants of the PDGF pathway genes associated ...
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Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy. 

Wen, Juyi; Liu, Hongliang; Wang, Lili; Wang, Xiaomeng; Gu, Ning; Liu, Zhensheng; Xu, Ting; ... (11 authors) (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018-05)
INTRODUCTION:Autophagy not only plays an important role in the progression of cancer but is also involved in tissue inflammatory response. However, few published studies have investigated associations between functional ...

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Author
Liu, Hongliang (8)
Wei, Qingyi (8)
Liu, Zhensheng (3)Wang, Yanru (3)Duan, Bensong (2)Owzar, Kouros (2)Wang, Li-E (2)Xie, Jichun (2)Abbruzzese, James (1)Abbruzzese, James L (1)... View MoreDate Issued2018 (4)2011 (1)2012 (1)2015 (1)2019 (1)TypeJournal article (8)Subject
Genetic Predisposition to Disease (8)
Humans (8)
Polymorphism, Single Nucleotide (8)
Genotype (5)Middle Aged (5)Male (4)Risk Factors (4)Aged (3)Case-Control Studies (3)Female (3)... View MoreAffiliation of Duke Author(s)Clinical Science Departments (8)Duke (8)Duke Cancer Institute (8)Institutes and Centers (8)
Medicine (8)
Medicine, Medical Oncology (8)School of Medicine (8)Basic Science Departments (7)Population Health Sciences (7)Biostatistics & Bioinformatics (4)... View More
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