Now showing items 1-10 of 11
Adsorption of a Nonionic Symmetric Triblock Copolymer on Surfaces with Different Hydrophobicity
This study investigates the adsorption of a symmetric triblock nonionic polymer comprising ethylene oxide (EO) and propylene oxide (PO) blocks (Pluronic P-105, EO37PO56EO37) on a range of substrates including hydrophobic, ...
Theoretical Framework for Nanoparticle Reactivity as a Function of Aggregation State
Theory is developed that relates the reactivity of nanoparticles to the structure of aggregates they may form in suspensions. This theory is applied to consider the case of reactive oxygen species (ROS) generation ...
Calcium Dependence of Fibrin Nanomechanics: The gamma 1 Calcium Mediates the Unfolding of Fibrinogen Induced by Force Applied to the "A-a" Bond
The interactions between the constituent monomers of fibrin, the polymerized protein network that provides the structural stability of blood clots, ale frequently under stress because of the dynamic nature of blood flow ...
Kinetic Parameters from Detection Probability in Single Molecule Force Spectroscopy
The detection probability of rupture events in A FM force spectroscopy measurements presents a viable alternative to standard methods for extracting kinetic parameters of dissociation. The detection probability has a maximum ...
Mechanical Distortion of Protein Receptor Decreases the Lifetime of a Receptor-Ligand Bond
Substantial experimental evidence indicates that the mechanical force applied to pull apart non-covalent molecular bonds (such as receptor ligand pairs) can significantly decrease the bond lifetime. This evidence is often ...
The Red and the Black
Pigmentation, which is primarily determined by the amount, the type, and the distribution of melanin, shows a remarkable diversity in human populations, and in this sense, it is an atypical trait.-E.J. Parra. Melanin is ...
Tunable Leuko-polymersomes That Adhere Specifically to Inflammatory Markers
The polymersome, a fully synthetic cell mimetic, is a tunable platform for drug delivery vehicles to detect and treat disease (theranostics). Here, we design a leuko-polymersome, a polymersome with the adhesive properties ...
Direct carbon-carbon bond formation via soft enolization: aldol addition of alpha-halogenated thioesters
alpha-Halo thioesters undergo soft enolization and syn-selective direct aldol addition to aldehydes in the presence of MgBr2 center dot OEt2 and i-Pr2NEt to produce alpha-halo-beta-hydroxy thioesters.
Direct Carbon-Carbon Bond Formation via Reductive Soft Enolization: A Kinetically Controlled syn-Aldol Addition of alpha-Halo Thioesters and Enolizable Aldehydes
The direct addition of enolizable aldehydes and a-halo thioesters to produce beta-hydroxy thioesters enabled by reductive soft enolization is reported. The transformation is operationally simple and efficient and has the ...