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Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion.
(eLife, 2016-03-22)
In the absence of salient sensory cues to guide behavior, animals must still execute
sequences of motor actions in order to forage and explore. How such successive motor
actions are coordinated to form global locomotion ...
Mapping nonlinear receptive field structure in primate retina at single cone resolution.
(eLife, 2015-10-30)
The function of a neural circuit is shaped by the computations performed by its interneurons,
which in many cases are not easily accessible to experimental investigation. Here,
we elucidate the transformation of visual signals ...
Behavioural and physiological limits to vision in mammals.
(Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017-04)
Human vision is exquisitely sensitive-a dark-adapted observer is capable of reliably
detecting the absorption of a few quanta of light. Such sensitivity requires that
the sensory receptors of the retina, rod photoreceptors, ...
Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.
(PloS one, 2012-01)
It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic
encephalopathy (HIE). Many women use some form of analgesia during childbirth and
some anesthetic agents have been shown to be neuroprotective ...
Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats.
(Journal of neurophysiology, 2017-07)
We have determined the impact of rod death and cone reorganization on the spatiotemporal
receptive fields (RFs) and spontaneous activity of distinct retinal ganglion cell
(RGC) types. We compared RGC function between healthy ...
A craniofacial-specific monosynaptic circuit enables heightened affective pain.
(Nature neuroscience, 2017-12)
Humans often rank craniofacial pain as more severe than body pain. Evidence suggests
that a stimulus of the same intensity induces stronger pain in the face than in the
body. However, the underlying neural circuitry for ...
TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.
(Nat Commun, 2014-09-02)
Animals need to sense and react to potentially dangerous environments. TRP ion channels
participate in nociception, presumably via Ca(2+) influx, in most animal species.
However, the relationship between ion permeation and ...
A whole-cell and single-channel study of the voltage-dependent outward potassium current in avian hepatocytes.
(J Gen Physiol, 1988-02)
Voltage-dependent membrane currents were studied in dissociated hepatocytes from chick,
using the patch-clamp technique. All cells had voltage-dependent outward K+ currents;
in 10% of the cells, a fast, transient, ...
Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.
(PLoS One, 2014)
Female sex is associated with improved outcome in experimental brain injury models,
such as traumatic brain injury, ischemic stroke, and intracerebral hemorrhage. This
implies female gonadal steroids may be neuroprotective. ...
Dopamine regulation of human speech and bird song: a critical review.
(Brain Lang, 2012-09)
To understand the neural basis of human speech control, extensive research has been
done using a variety of methodologies in a range of experimental models. Nevertheless,
several critical questions about learned vocal motor ...