Now showing items 1-10 of 264
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ...
The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway.
(Eur J Neurosci, 2007-04)
The discrete neural network for songbird vocal communication provides an effective system to study neural mechanisms of learned motor behaviors in vertebrates. This system consists of two pathways--a vocal motor pathway ...
Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species.
(Genome Biol, 2014)
BACKGROUND: Nearly one-quarter of all avian species is either threatened or nearly threatened. Of these, 73 species are currently being rescued from going extinct in wildlife sanctuaries. One of the previously most ...
Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Global view of the functional molecular organization of the avian cerebrum: mirror images and functional columns.
(J Comp Neurol, 2013-11)
Based on quantitative cluster analyses of 52 constitutively expressed or behaviorally regulated genes in 23 brain regions, we present a global view of telencephalic organization of birds. The patterns of constitutively expressed ...
Comparative genomics reveals insights into avian genome evolution and adaptation.
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. ...
Radioactive in situ hybridization for detecting diverse gene expression patterns in tissue.
(J Vis Exp, 2012-04-27)
Knowing the timing, level, cellular localization, and cell type that a gene is expressed in contributes to our understanding of the function of the gene. Each of these features can be accomplished with in situ hybridization ...
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells.
(J Clin Invest, 2015-02)
Satiety and other core physiological functions are modulated by sensory signals arising from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors called enteroendocrine cells. Despite being ...
Hybrid de novo genome assembly and centromere characterization of the gray mouse lemur (Microcebus murinus).
(BMC biology, 2017-11-16)
The de novo assembly of repeat-rich mammalian genomes using only high-throughput short read sequencing data typically results in highly fragmented genome assemblies that limit downstream applications. Here, we present an ...
Astrocytes refine cortical connectivity at dendritic spines.
During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this ...