Now showing items 1661-1670 of 1677
Boron and strontium isotopic characterization of coal combustion residuals: validation of new environmental tracers.
(Environ Sci Technol, 2014-12-16)
In the U.S., coal fired power plants produce over 136 million tons of coal combustion residuals (CCRs) annually. CCRs are enriched in toxic elements, and their leachates can have significant impacts on water quality. Here ...
An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer.
(J Clin Invest, 2010-09)
Therapeutic anticancer vaccines are designed to boost patients' immune responses to tumors. One approach is to use a viral vector to deliver antigen to in situ DCs, which then activate tumor-specific T cell and antibody ...
Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.
(J Neurotrauma, 2010-11)
Cognitive impairment is common following traumatic brain injury (TBI), and neuroinflammatory mechanisms may predispose to the development of neurodegenerative disease. Apolipoprotein E (apoE) polymorphisms modify ...
Extreme events reveal an alimentary limit on sustained maximal human energy expenditure.
(Science advances, 2019-06-05)
The limits on maximum sustained energy expenditure are unclear but are of interest because they constrain reproduction, thermoregulation, and physical activity. Here, we show that sustained expenditure in humans, measured ...
Neural activation for actual and imagined movement following unilateral hand transplantation: a case study.
Transplantation of a donor hand has been successful as a surgical treatment following amputation, but little is known regarding the brain mechanisms contributing to the recovery of motor function. We report functional magnetic ...
Clinical Workflow and Substance Use Screening, Brief Intervention, and Referral to Treatment Data in the Electronic Health Records: A National Drug Abuse Treatment Clinical Trials Network Study.
Introduction:The use of electronic health records (EHR) data in research to inform recruitment and outcomes is considered a critical element for pragmatic studies. However, there is a lack of research on the availability ...
Trends in Place of Death for Individuals With Cardiovascular Disease in the United States
(Journal of the American College of Cardiology, 2019-10-15)
Hip extensor mechanics and the evolution of walking and climbing capabilities in humans, apes, and fossil hominins.
(Proceedings of the National Academy of Sciences of the United States of America, 2018-04-02)
The evolutionary emergence of humans' remarkably economical walking gait remains a focus of research and debate, but experimentally validated approaches linking locomotor capability to postcranial anatomy are limited. In ...
A host gene expression approach for identifying triggers of asthma exacerbations.
(PloS one, 2019-01)
RATIONALE:Asthma exacerbations often occur due to infectious triggers, but determining whether infection is present and whether it is bacterial or viral remains clinically challenging. A diagnostic strategy that clarifies ...