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Now showing items 11-20 of 53
Joint analysis of health histories, physiological state, and survival
(Mathematical Population Studies, 2011-12-01)
Data on individual health histories, age trajectories of physiological or biological
variables, and mortality allow for the study of the joint evolution of health and
physiological states and their effects on mortality. ...
Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.
(Health Phys, 2010-09)
A new model of the hematopoietic system for humans chronically exposed to ionizing
radiation allows for quantitative description of the initial hematopoiesis inhibition
and subsequent increase in the risks of late stochastic ...
How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.
(N Am Actuar J, 2016)
BACKGROUND AND OBJECTIVE: To clarify mechanisms of genetic regulation of human aging
and longevity traits, a number of genome-wide association studies (GWAS) of these
traits have been performed. However, the results of these ...
The role of lipid-related genes, aging-related processes, and environment in healthspan
(Aging Cell, 2013)
The inherent complexity of aging-related traits can temper progress in unraveling
the genetic origins of healthspan. We focus on two generations in the Framingham Heart
Study, the original (FHS) and offspring (FHSO) cohorts, ...
stpm: an R package for stochastic process model.
(BMC Bioinformatics, 2017-02-23)
BACKGROUND: The Stochastic Process Model (SPM) represents a general framework for
modeling the joint evolution of repeatedly measured variables and time-to-event outcomes
observed in longitudinal studies, i.e., SPM relates ...
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.
(Rejuvenation Res, 2015-04)
The lack of evolutionary established mechanisms linking genes to age-related traits
makes the problem of genetic susceptibility to health span inherently complex. One
complicating factor is genetic trade-off. Here we focused ...
How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.
(Biogerontology, 2016-02)
Increasing proportions of elderly individuals in developed countries combined with
substantial increases in related medical expenditures make the improvement of the
health of the elderly a high priority today. If the process ...
Genetics of aging, health, and survival: dynamic regulation of human longevity related traits.
(Front Genet, 2015)
BACKGROUND: The roles of genetic factors in human longevity would be better understood
if one can use more efficient methods in genetic analyses and investigate pleiotropic
effects of genetic variants on aging and health ...
The role of lipid-related genes, aging-related processes, and environment in healthspan.
(Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling
the genetic origins of healthspan. We focus on two generations in the Framingham Heart
Study, the original (FHS) and offspring (FHSO) cohorts, ...