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    Now showing items 11-20 of 53

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    Joint analysis of health histories, physiological state, and survival 

    Akushevich, Igor; Arbeev, Konstantin; Kulminski, Alexander; Ukraintseva, Svetlana; Yashin, Anatoli I (Mathematical Population Studies, 2011-12-01)
    Data on individual health histories, age trajectories of physiological or biological variables, and mortality allow for the study of the joint evolution of health and physiological states and their effects on mortality. ...
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    Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts. 

    Akleyev, AV; Akushevich, Igor; Arbeev, Konstantin; Dimov, GP; Ukraintseva, Svetlana; Veremeyeva, Galina A; Yashin, Anatoli I (Health Phys, 2010-09)
    A new model of the hematopoietic system for humans chronically exposed to ionizing radiation allows for quantitative description of the initial hematopoiesis inhibition and subsequent increase in the risks of late stochastic ...
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    MEDICARE-BASED MULTIMORBIDITY INDEX FOR PROJECTING MORBIDITY AND MORTALITY AMONG OLDER ADULTS IN THE U.S 

    Akushevich, Igor; Arbeev, Konstantin; Cohen, Harvey Jay; Kravchenko, J; Ukraintseva, Svetlana; Whitson, Heather Elizabeth; Yashin, Anatoli I (GERONTOLOGIST, 2012-11)
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    How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data. 

    Akushevich, Igor; Arbeev, Konstantin; Arbeeva, L; Kulminskaya, Irina; Kulminski, Alexander; Ukraintseva, Svetlana; Wu, Dequing; ... (8 authors) (N Am Actuar J, 2016)
    BACKGROUND AND OBJECTIVE: To clarify mechanisms of genetic regulation of human aging and longevity traits, a number of genome-wide association studies (GWAS) of these traits have been performed. However, the results of these ...
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    The role of lipid-related genes, aging-related processes, and environment in healthspan 

    Arbeev, Konstantin; Arbeeva, L; Culminskaya, IV; Kulminski, Alexander; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Aging Cell, 2013)
    The inherent complexity of aging-related traits can temper progress in unraveling the genetic origins of healthspan. We focus on two generations in the Framingham Heart Study, the original (FHS) and offspring (FHSO) cohorts, ...
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    stpm: an R package for stochastic process model. 

    Akushevich, Igor; Arbeev, Konstantin; Stallard, Eric; Yashin, Anatoli I; Zhbannikov, Ilya (BMC Bioinformatics, 2017-02-23)
    BACKGROUND: The Stochastic Process Model (SPM) represents a general framework for modeling the joint evolution of repeatedly measured variables and time-to-event outcomes observed in longitudinal studies, i.e., SPM relates ...
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    Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study. 

    Arbeev, Konstantin; Culminskaya, IV; Kulminski, Alexander; Province, MA; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Rejuvenation Res, 2015-04)
    The lack of evolutionary established mechanisms linking genes to age-related traits makes the problem of genetic susceptibility to health span inherently complex. One complicating factor is genetic trade-off. Here we focused ...
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    How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity. 

    Akushevich, Igor; Arbeev, Konstantin; Arbeeva, LS; Culminskaya, IV; Kovtun, Mikhail; Kulminski, Alexander; Li, M; ... (12 authors) (Biogerontology, 2016-02)
    Increasing proportions of elderly individuals in developed countries combined with substantial increases in related medical expenditures make the improvement of the health of the elderly a high priority today. If the process ...
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    Genetics of aging, health, and survival: dynamic regulation of human longevity related traits. 

    Akushevich, Igor; Arbeev, Konstantin; Arbeeva, LS; Culminskaya, IV; Kovtun, Mikhail; Kulminski, Alexander; Li, M; ... (11 authors) (Front Genet, 2015)
    BACKGROUND: The roles of genetic factors in human longevity would be better understood if one can use more efficient methods in genetic analyses and investigate pleiotropic effects of genetic variants on aging and health ...
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    The role of lipid-related genes, aging-related processes, and environment in healthspan. 

    Arbeev, Konstantin; Arbeeva, L; Culminskaya, IV; Kulminski, Alexander; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Aging Cell, 2013-04)
    The inherent complexity of aging-related traits can temper progress in unraveling the genetic origins of healthspan. We focus on two generations in the Framingham Heart Study, the original (FHS) and offspring (FHSO) cohorts, ...
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    Arbeev, Konstantin (53)
    Yashin, Anatoli I (53)Ukraintseva, Svetlana (44)Akushevich, Igor (32)Kulminski, Alexander (32)Culminskaya, IV (19)Stallard, Eric (18)Wu, Dequing (13)Arbeeva, L (12)Kravchenko, J (12)... View MoreDate Issued2013 (13)2011 (9)2012 (9)2010 (8)2016 (5)2015 (4)2017 (3)2014 (2)TypeJournal article (52)Conference (1)SubjectHumans (32)Female (23)Male (23)Longevity (16)Aging (15)Aged (14)Adult (11)Aged, 80 and over (11)Cohort Studies (11)Middle Aged (11)... View MoreAffiliation of Duke Author(s)Center for Population Health & Aging (53)Duke (53)Duke Cancer Institute (53)
    Duke Population Research Center (53)
    Duke Population Research Institute (53)Institutes and Centers (53)Institutes and Provost's Academic Units (53)
    Sanford School of Public Policy (53)
    School of Medicine (53)
    Social Science Research Institute (53)... View More