Now showing items 11-20 of 975
Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
(Mol Cell Biol, 2004-10)
beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between ...
Global chronic disease research training for fellows: perspectives, challenges, and opportunities.
Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer.
(BMC Cancer, 2010-10-06)
BACKGROUND: The Exercise Intensity Trial (EXcITe) is a randomized trial to compare the efficacy of supervised moderate-intensity aerobic training to moderate to high-intensity aerobic training, relative to attention control, ...
Educational interventions to improve recognition of delirium: a systematic review.
(J Am Geriatr Soc, 2013-11)
Delirium is a common and serious condition that is underrecognized in older adults in a variety of healthcare settings. It is poorly recognized because of deficiencies in provider knowledge and its atypical presentation. ...
Systematic review and metasummary of attitudes toward research in emergency medical conditions.
(J Med Ethics, 2014-06)
Emergency departments are challenging research settings, where truly informed consent can be difficult to obtain. A deeper understanding of emergency medical patients' opinions about research is needed. We conducted a systematic ...
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
(PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome ...
Study protocol: home-based telehealth stroke care: a randomized trial for veterans.
BACKGROUND: Stroke is one of the most disabling and costly impairments of adulthood in the United States. Stroke patients clearly benefit from intensive inpatient care, but due to the high cost, there is considerable interest ...
Avelumab in patients with previously treated metastatic adrenocortical carcinoma: phase 1b results from the JAVELIN solid tumor trial.
(Journal for immunotherapy of cancer, 2018-10-22)
BACKGROUND:We assessed the efficacy and safety of avelumab, an anti-programmed death ligand 1 (PD-L1) antibody, in patients with previously treated metastatic adrenocortical carcinoma (mACC). METHODS:In this phase 1b expansion ...
Lifetime prevalence of intimate partner violence against women in an urban Brazilian city: A cross-sectional survey.
(PloS one, 2019-01)
BACKGROUND:Intimate partner violence is a global health burden that disproportionately affects women and their health outcomes. Women in Brazil are also affected by interpersonal violence. We aimed to estimate the lifetime ...