Search
Now showing items 11-20 of 58
Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.
(J Thorac Cardiovasc Surg, 2014-04)
OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality
has been challenged. The conflicting results might have resulted from the extent of
BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ...
Early hematopoiesis inhibition under chronic radiation exposure in humans.
(Radiat Environ Biophys, 2010-05)
The major goal of this study was to identify and quantitatively describe the association
between the characteristics of chronic (low-dose rate) exposure to (low LET) ionizing
radiation and cellularity of peripheral blood ...
A Systematic Review of Conceptual Frameworks of Medical Complexity and New Model Development.
(J Gen Intern Med, 2016-03)
BACKGROUND: Patient complexity is often operationalized by counting multiple chronic
conditions (MCC) without considering contextual factors that can affect patient risk
for adverse outcomes. OBJECTIVE: Our objective was ...
Breast cancer as heterogeneous disease: contributing factors and carcinogenesis mechanisms.
(Breast Cancer Res Treat, 2011-07)
The observed bimodal patterns of breast cancer incidence in the U.S. suggested that
breast cancer may be viewed as more than one biological entity. We studied the factors
potentially contributing to this phenomenon, specifically ...
Radiative corrections beyond the ultra relativistic limit in unpolarized ep elastic and Møller scatterings for the PRad Experiment at Jefferson Laboratory
(European Physical Journal A, 2015-01-01)
© 2015, SIF, Springer-Verlag Berlin Heidelberg.The clear 7σ discrepancy between measurements
of the proton charge radius from muonic hydrogen Lamb shifts and those from hydrogen
Lamb shift and electron scattering lead to ...
Benefit of adjuvant chemotherapy after resection of stage II (T1-2N1M0) non-small cell lung cancer in elderly patients.
(Ann Surg Oncol, 2015-02)
BACKGROUND: We evaluated the use and efficacy of adjuvant chemotherapy after resection
of T1-2N1M0 non-small cell lung cancer (NSCLC) in elderly patients. METHODS: Factors
associated with the use of adjuvant chemotherapy ...
Trade-offs between cancer and other diseases: do they exist and influence longevity?
(Rejuvenation Res, 2010-08)
Relationships between aging, disease risks, and longevity are not yet well understood.
For example, joint increases in cancer risk and total survival observed in many human
populations and some experimental aging studies ...
Joint analysis of health histories, physiological state, and survival
(Mathematical Population Studies, 2011-12-01)
Data on individual health histories, age trajectories of physiological or biological
variables, and mortality allow for the study of the joint evolution of health and
physiological states and their effects on mortality. ...
Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.
(Health Phys, 2010-09)
A new model of the hematopoietic system for humans chronically exposed to ionizing
radiation allows for quantitative description of the initial hematopoiesis inhibition
and subsequent increase in the risks of late stochastic ...
How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.
(N Am Actuar J, 2016)
BACKGROUND AND OBJECTIVE: To clarify mechanisms of genetic regulation of human aging
and longevity traits, a number of genome-wide association studies (GWAS) of these
traits have been performed. However, the results of these ...