Search
Now showing items 21-30 of 67
Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.
(Journal of cellular and molecular medicine, 2016-04)
Ethnic Han Chinese are at high risk of developing oesophageal squamous cell carcinoma
(ESCC). Aberrant activation of the AKT signalling pathway is involved in many cancers,
including ESCC. Some single nucleotide polymorphisms ...
Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk.
(International journal of cancer, 2018-04)
The platelet-derived growth factor (PDGF) signaling pathway plays important roles
in development and progression of human cancers. In our study, we aimed to identify
genetic variants of the PDGF pathway genes associated ...
On the interplay of telomeres, nevi and the risk of melanoma.
(PloS one, 2012-01)
The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres
have been found to be associated with many cancers and with number of nevi, a known
risk factor for melanoma. However, shorter telomeres ...
Association between XPF polymorphisms and cancer risk: a meta-analysis.
(PloS one, 2012-01)
BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key
role in DNA repair that protects against genetic instability and carcinogenesis. A
series of epidemiological studies have examined associations ...
Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study.
(Oncotarget, 2016-09)
The Notch signaling pathway has been shown to have biological significance and therapeutic
application in non-small cell lung cancer (NSCLC). We hypothesize that genetic variants
of genes in the Notch signaling pathway are ...
Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer.
(International journal of cancer, 2018-11)
The toll-like receptor (TLR) signaling pathway plays an important role in the innate
immune responses and antigen-specific acquired immunity. Aberrant activation of the
TLR pathway has a significant impact on carcinogenesis ...
Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.
(Oncotarget, 2016-03)
Published data on the association between the MUC1 rs4072037A > G polymorphism and
gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of
the association, we conducted a large GCa study of 1,124 ...
TGFβ1 Polymorphisms Predict Distant Metastasis-Free Survival in Patients with Inoperable Non-Small-Cell Lung Cancer after Definitive Radiotherapy.
(PloS one, 2013-01)
Transforming growth factor (TGF) -β1 signaling is involved in cancer-cell metastasis.
We investigated whether single nucleotide polymorphisms (SNPs) at TGFβ1 were associated
with overall survival (OS) and distant metastasis-free ...
An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy.
(International journal of cancer, 2018-03)
Platinum-based chemotherapy (PBC) in combination with the 3rd generation drugs is
the first-line treatment for patients with advanced non-small cell lung cancer (NSCLC);
however, the efficacy is severely hampered by grade ...
Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
(PloS one, 2013-01)
BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis
pathway and plays a crucial role in cancer development and progression. However, few
studies have evaluated associations between functional ...