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Chromosomal organization of adrenergic receptor genes.
(Proc Natl Acad Sci U S A, 1990-02)
The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are
a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors
that mediate the physiological effects of the hormone ...
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
(Proc Natl Acad Sci U S A, 1995-08-29)
Phosphorylation of G-protein-coupled receptors plays an important role in regulating
their function. In this study the G-protein-coupled receptor phosphatase (GRP) capable
of dephosphorylating G-protein-coupled receptor ...
Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells.
(Endocrinology, 1997-01)
Proliferation of thyroid follicular cells is controlled by three intra-cellular cascades
[cAMP, inositol 1,4,5-triphosphate (IP3)/Ca2+/diacylglycerol (DAG), and tyrosine kinases]
that are activated by distinct extracellular ...
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
(Proc Natl Acad Sci U S A, 1994-12-20)
Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein
kinases (MAP kinases). In several cell types, this appears to be dependent on the
activation of p21ras (Ras). Which G-protein subunit(s) ...
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
(J Neurosci, 1992-10)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied
beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating
adenylyl cyclase activity. Beta ARK-mediated receptor ...
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.
(Circulation, 1998-10-27)
BACKGROUND: Impaired myocardial beta-adrenergic receptor (betaAR) signaling, including
desensitization and functional uncoupling, is a characteristic of congestive heart
failure. A contributing mechanism for this impairment ...
Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.
(Genes Dev, 1998-07-15)
Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all
eukaryotic cells. Cyclin B1 localization changes dramatically during the cell cycle,
precipitously transiting from the cytoplasm to the nucleus ...
Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
(Proc Natl Acad Sci U S A, 1997-03-18)
The G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate and desensitize
agonist-occupied GPCRs. GRK2-mediated receptor phosphorylation is preceded by the
agonist-dependent membrane association of this enzyme. ...
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
(Circ Res, 1999-01-08)
-Transgenic mouse models have been developed to manipulate beta-adrenergic receptor
(betaAR) signal transduction. Although several of these models have altered betaAR
subtypes, the specific functional sequelae of betaAR ...
Mitogenic signaling via G protein-coupled receptors.
(Endocr Rev, 1996-12)