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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.
(J Exp Med, 1992-09-01)
In the genetically restricted response that follows immunization with (4-hydroxy-3-nitrophenyl)acetyl
coupled to protein carriers, two distinct populations of B cells are observed in the
spleens of C57BL/6 mice. By 48 h ...
Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
(Br J Cancer, 1996-05)
The biodistribution of no-carrier-added (n.c.a.) meta-[131I]iodobenzylguanidine ([131I]MIBG)
and that prepared by the standard isotopic exchange method were compared in athymic
mice bearing SK-N-SH human neuroblastoma xenografts. ...
Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice.
(J Exp Med, 1999-08-02)
The role of apoptosis in affinity maturation was investigated by determining the affinity
of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific antibody-forming cells (AFCs) and
serum antibody in transgenic mice that overexpress ...
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.
(J Exp Med, 1993-10-01)
In the murine spleen, germinal centers are the anatomic sites for antigen-driven hypermutation
and selection of immunoglobulin (Ig) genes. To detail the kinetics of Ig mutation
and selection, 178 VDJ sequences from ...
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.
(J Exp Med, 1991-05-01)
After primary immunization with an immunogenic conjugate of (4-hydroxy-3-nitrophenyl)acetyl,
two anatomically and phenotypically distinct populations of antibody-forming cells
arise in the spleen. As early as 2 ...
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.
(J Exp Med, 1995-12-01)
Germinal centers (GCs) are the sites of antigen-driven V(D)J gene hypermutation and
selection necessary for the generation of high affinity memory B lymphocytes. Despite
the antigen dependence of this reaction, injection ...
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.
(J Exp Med, 1998-03-16)
To examine the role of germinal centers (GCs) in the generation and selection of high
affinity antibody-forming cells (AFCs), we have analyzed the average affinity of (4-hydroxy-3-nitrophenyl)acetyl
(NP)-specific AFCs and ...
T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.
(J Exp Med, 1996-09-01)
After immunization, activated splenic T cells proliferate in periarteriolar lymphoid
sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter
nascent germinal centers. Analysis of TCR V(D)J gene ...
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
(Proc Natl Acad Sci U S A, 1998-11-24)
G protein-coupled receptor activation leads to the membrane recruitment and activation
of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their
inactivation. We have identified a novel ...
