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Morbidity risks among older adults with pre-existing age-related diseases.

Akushevich, Igor; Arbeev, Konstantin; Kravchenko, J; Kulminski, Alexander; Ukraintseva, Svetlana; Yashin, Anatoli I (Exp Gerontol, 2013-12)

Multi-morbidity is common among older adults; however, for many aging-related diseases there is no information for U.S. elderly population on how earlier-manifested disease affects the risk of another disease manifested ...

Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.

Arbeev, Konstantin; Arbeeva, L; Culminskaya, IV; Kulminski, Alexander; Stallard, Eric; Ukraintseva, Svetlana; Wu, Dequing; ... (8 authors) (PLoS One, 2015)

Insights into genetic origin of diseases and related traits could substantially impact strategies for improving human health. The results of genome-wide association studies (GWAS) are often positioned as discoveries ...

Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.

Arbeev, Konstantin; Arbeeva, L; Culminskaya, IV; Kulminski, Alexander; Ukraintseva, Svetlana; Yashin, Anatoli I (Rejuvenation Res, 2013-02)

Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring ...

Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.

Arbeev, Konstantin; Arbeeva, L; Christensen, Kaare; Culminskaya, IV; Kulminski, Alexander; Province, MA; Schupf, N; ... (10 authors) (PLoS Genet, 2014-01)

Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ...