Now showing items 41-50 of 87
Genetics of aging, health, and survival: dynamic regulation of human longevity related traits.
(Front Genet, 2015)
BACKGROUND: The roles of genetic factors in human longevity would be better understood if one can use more efficient methods in genetic analyses and investigate pleiotropic effects of genetic variants on aging and health ...
The role of lipid-related genes, aging-related processes, and environment in healthspan.
(Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling the genetic origins of healthspan. We focus on two generations in the Framingham Heart Study, the original (FHS) and offspring (FHSO) cohorts, ...
Modeling longitudinal data on health aging and life span
(Physics of Life Reviews, 2012-06-01)
We address comments from the three discussants of our paper, paying particular attention to the properties of our model likely to be of interest in new applications to complex dynamic systems. © 2012 Elsevier B.V.
PATTERNS OF AGING-RELATED DISEASES INCIDENCE AND RECOVERY IN US ELDERLY
Early hematopoietic effects of chronic radiation exposure in humans.
(Health Phys, 2010-09)
The major goal of this study is to investigate and quantitatively describe the nature of the relationship between the characteristics of chronic exposure to ionizing radiation and specific patterns of hematopoiesis reduction. ...
Age trajectories of physiological indices in relation to healthy life course.
(Mech Ageing Dev, 2011-03)
We analysed relationship between the risk of onset of "unhealthy life" (defined as the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes in body mass index, diastolic blood pressure, hematocrit, ...
Medical cost trajectories and onsets of cancer and noncancer diseases in US elderly population.
(Comput Math Methods Med, 2011)
Time trajectories of medical costs-associated with onset of twelve aging-related cancer and chronic noncancer diseases were analyzed using the National Long-Term Care Survey data linked to Medicare Service Use files. A special ...
Circulatory Diseases in the U.S. Elderly in the Linked National Long-Term Care Survey-Medicare Database: Population-Based Analysis of Incidence, Comorbidity, and Disability.
(Res Aging, 2013-07)
Incidence rates of acute coronary heart disease (ACHD; including myocardial infarction and angina pectoris), stroke, and heart failure (HF) were studied for their age, disability, and comorbidity patterns in the U.S. elderly ...
Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan
(PLoS Genetics, 2014-01-01)
Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ...