Now showing items 61-70 of 936
Cardiorespiratory fitness and cognitive function in midlife: neuroprotection or neuroselection?
(Ann Neurol, 2015-04)
OBJECTIVE: A study was undertaken to determine whether better cognitive functioning at midlife among more physically fit individuals reflects neuroprotection, by which fitness protects against age-related cognitive decline, ...
Psychiatric correlates of snuff and chewing tobacco use.
(PLoS One, 2014)
Compared to the association between cigarette smoking and psychiatric disorders, relatively little is known about the relationship between smokeless tobacco use and psychiatric disorders. To identify the psychiatric correlates ...
Astrocytes refine cortical connectivity at dendritic spines.
During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this ...
Preschool anxiety disorders predict different patterns of amygdala-prefrontal connectivity at school-age.
(PLoS One, 2015)
OBJECTIVE: In this prospective, longitudinal study of young children, we examined whether a history of preschool generalized anxiety, separation anxiety, and/or social phobia is associated with amygdala-prefrontal dysregulation ...
A neural biomarker of psychological vulnerability to future life stress.
We all experience a host of common life stressors such as the death of a family member, medical illness, and financial uncertainty. While most of us are resilient to such stressors, continuing to function normally, for a ...
Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates.
(PLoS One, 2014)
The Hedgehog (Hh) gene family codes for a class of secreted proteins composed of two active domains that act as signalling molecules during embryo development, namely for the development of the nervous and skeletal systems ...
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells
(JOURNAL OF CLINICAL INVESTIGATION, 2015-02)
Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
(J Policy Anal Manage, 2015)
Early interventions are a preferred method for addressing behavioral problems in high-risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve ...
Phylogenomic analyses data of the avian phylogenomics project.
BACKGROUND: Determining the evolutionary relationships among the major lineages of extant birds has been one of the biggest challenges in systematic biology. To address this challenge, we assembled or collected the genomes ...
Perspectives on genetic and genomic technologies in an academic medical center: the duke experience.
(Journal of personalized medicine, 2015-04-03)
In this age of personalized medicine, genetic and genomic testing is expected to become instrumental in health care delivery, but little is known about its actual implementation in clinical practice.We surveyed Duke faculty ...