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Cardiorespiratory fitness and cognitive function in midlife: neuroprotection or neuroselection?
(Ann Neurol, 2015-04)
OBJECTIVE: A study was undertaken to determine whether better cognitive functioning
at midlife among more physically fit individuals reflects neuroprotection, by which
fitness protects against age-related cognitive decline, ...
Psychiatric correlates of snuff and chewing tobacco use.
(PLoS One, 2014)
Compared to the association between cigarette smoking and psychiatric disorders, relatively
little is known about the relationship between smokeless tobacco use and psychiatric
disorders. To identify the psychiatric correlates ...
Astrocytes refine cortical connectivity at dendritic spines.
(Elife, 2014-12-17)
During cortical synaptic development, thalamic axons must establish synaptic connections
despite the presence of the more abundant intracortical projections. How thalamocortical
synapses are formed and maintained in this ...
Preschool anxiety disorders predict different patterns of amygdala-prefrontal connectivity at school-age.
(PLoS One, 2015)
OBJECTIVE: In this prospective, longitudinal study of young children, we examined
whether a history of preschool generalized anxiety, separation anxiety, and/or social
phobia is associated with amygdala-prefrontal dysregulation ...
A neural biomarker of psychological vulnerability to future life stress.
(Neuron, 2015-02-04)
We all experience a host of common life stressors such as the death of a family member,
medical illness, and financial uncertainty. While most of us are resilient to such
stressors, continuing to function normally, for a ...
Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates.
(PLoS One, 2014)
The Hedgehog (Hh) gene family codes for a class of secreted proteins composed of two
active domains that act as signalling molecules during embryo development, namely
for the development of the nervous and skeletal systems ...
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells
(JOURNAL OF CLINICAL INVESTIGATION, 2015-02)
Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
(J Policy Anal Manage, 2015)
Early interventions are a preferred method for addressing behavioral problems in high-risk
children, but often have only modest effects. Identifying sources of variation in
intervention effects can suggest means to improve ...
Phylogenomic analyses data of the avian phylogenomics project.
(Gigascience, 2015)
BACKGROUND: Determining the evolutionary relationships among the major lineages of
extant birds has been one of the biggest challenges in systematic biology. To address
this challenge, we assembled or collected the genomes ...
Perspectives on genetic and genomic technologies in an academic medical center: the duke experience.
(Journal of personalized medicine, 2015-04-03)
In this age of personalized medicine, genetic and genomic testing is expected to become
instrumental in health care delivery, but little is known about its actual implementation
in clinical practice.We surveyed Duke faculty ...