Now showing items 1-10 of 716
Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.
(Cell host & microbe, 2018-06)
HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency. Probable mutations occur at sites of frequent ...
A Quantitative Approach to Predict Differential Effects of Anti-VEGF Treatment on Diffuse and Focal Leakage in Patients with Diabetic Macular Edema: A Pilot Study.
(Translational vision science & technology, 2017-03-21)
We use semiautomated segmentation of fluorescein angiography (FA) to determine whether anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) differentially affects microaneurysm (MA)-associated ...
A Mini Review of the Zoonotic Threat Potential of Influenza Viruses, Coronaviruses, Adenoviruses, and Enteroviruses.
(Frontiers in public health, 2018-01)
During the last two decades, scientists have grown increasingly aware that viruses are emerging from the human-animal interface. In particular, respiratory infections are problematic; in early 2003, World Health Organization ...
CABG or PCI for Diabetic Patients With Left Ventricular Dysfunction: Closing in on the Truth?
(Journal of the American College of Cardiology, 2018-02)
Sensorimotor learning during a marksmanship task in immersive virtual reality
(Frontiers in Psychology, 2018-02-06)
Sensorimotor learning refers to improvements that occur through practice in the performance of sensory-guided motor behaviors. Leveraging novel technical capabilities of an immersive virtual environment, we probed the component ...
Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM).
(American journal of obstetrics and gynecology, 2018-07)
Preterm premature rupture of membranes is a leading contributor to maternal and neonatal morbidity and death. Epidemiologic and experimental studies have demonstrated that thrombin causes fetal membrane weakening and subsequently ...
The cochlear implant and possibilities for narrowing the remaining gaps between prosthetic and normal hearing.
(World journal of otorhinolaryngology - head and neck surgery, 2017-12)
The cochlear implant has become the standard of care for severe or worse losses in hearing and indeed has produced the first substantial restoration of a lost or absent human sense using a medical intervention. However, ...
Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.
(PloS one, 2012-01)
It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic encephalopathy (HIE). Many women use some form of analgesia during childbirth and some anesthetic agents have been shown to be neuroprotective ...
Reprint of ''Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention''.
The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance ...
Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact.
A common strategy by which developing neurons locate their synaptic partners is through projections to circuit-specific neuropil sublayers. Once established, sublayers serve as a substrate for selective synapse formation, ...