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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.

Cao, L; Fermor, B; Griffin, TM; Guilak, Farshid; Huebner, JL; Kraus, Virginia Byers; Rodriguiz, Ramona M; ... (9 authors) (Arthritis Res Ther, 2010)

INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ...

In Vivo luminescent imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis.

Bell, RD; Bowles, RD; Huebner, JL; Kraus, Virginia Byers; Mata, BA; Mwangi, TK; Setton, Lori A (Arthritis Rheum, 2013-11-18)

Objective: To investigate the relationship between NF-κB activity, cytokine levels, and pain sensitivities in a rodent model of osteoarthritis (OA). Method: OA was induced in transgenic NF-κB luciferase reporter mice via ...