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A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.
(BMC Bioinformatics, 2013-12-16)
BACKGROUND: The goal of many proteomics experiments is to determine the abundance
of proteins in biological samples, and the variation thereof in various physiological
conditions. High-throughput quantitative proteomics, ...
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
(Arthritis Res Ther, 2016-04-12)
BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our
objective was to explore the relationships of GlycA, a measure of glycosylated acute
phase proteins, with inflammation and cardiometabolic ...
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis.
(Arthritis Res Ther, 2012-04-17)
INTRODUCTION: Osteoarthritis (OA) results in pain and disability; however, preclinical
OA models often focus on joint-level changes. Gait analysis is one method used to
evaluate both preclinical OA models and OA patients. ...
Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.
(PLoS One, 2013)
Given the importance of cardiovascular disease (CVD) to public health and the demonstrated
heritability of both disease status and its related risk factors, identifying the
genetic variation underlying these susceptibilities ...
Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.
(Arthritis Res Ther, 2017-01-23)
BACKGROUND: To identify molecular alterations in skeletal muscle in rheumatoid arthritis
(RA) that may contribute to ongoing disability in RA. METHODS: Persons with seropositive
or erosive RA (n = 51) and control subjects ...
Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis.
(Arthritis Res Ther, 2014-06-25)
INTRODUCTION: Post-traumatic arthritis (PTA) is a progressive, degenerative response
to joint injury, such as articular fracture. The pro-inflammatory cytokines, interleukin
1(IL-1) and tumor necrosis factor alpha (TNF-α), ...
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
(PLoS One, 2012)
OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma
metabolic intermediates in response to a mixed meal, suggestive of changes in the
capacity to adapt fuel oxidation to fuel availability or ...
Critical appraisal of four IL-6 immunoassays.
(PLoS One, 2012)
BACKGROUND: Interleukin-6 (IL-6) contributes to numerous inflammatory, metabolic,
and physiologic pathways of disease. We evaluated four IL-6 immunoassays in order
to identify a reliable assay for studies of metabolic and ...
Progress in intra-articular therapy.
(Nat Rev Rheumatol, 2014-01)
Diarthrodial joints are well suited to intra-articular injection, and the local delivery
of therapeutics in this fashion brings several potential advantages to the treatment
of a wide range of arthropathies. Possible benefits ...