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Biogenetic Mechanisms Predisposing to Complex Phenotypes in Parents May Function Differently in Their Children

Arbeev, Konstantin; Barmada, M; Christensen, Kaare; Kulminski, Alexander; Miljkovic, I; Stallard, Eric; Yashin, Anatoli I (JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2013-07)

Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.

Arbeev, Konstantin; Arbeeva, L; Christensen, Kaare; Culminskaya, IV; Kulminski, Alexander; Province, MA; Schupf, N; ... (10 authors) (PLoS Genet, 2014-01)

Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ...