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Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
(Hypertension, 1999-01)
Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic
receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1,
which phosphorylates and desensitizes beta-adrenergic ...
G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.
(Arterioscler Thromb Vasc Biol, 1998-08)
Vein grafting results in the development of intimal hyperplasia with accompanying
changes in guanine nucleotide-binding (G) protein expression and function. Several
serum mitogens that act through G protein-coupled receptors, ...
Adrenergic receptors. Models for regulation of signal transduction processes.
(Hypertension, 1990-02)
Adrenergic receptors are prototypic models for the study of the relations between
structure and function of G protein-coupled receptors. Each receptor is encoded by
a distinct gene. These receptors are integral membrane ...
Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.
(Proc Natl Acad Sci U S A, 1992-07-01)
A number of lines of evidence suggest that cross-talk exists between the cellular
signal transduction pathways involving tyrosine phosphorylation catalyzed by members
of the pp60c-src kinase family and those mediated by ...
Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.
(Proc Natl Acad Sci U S A, 1990-07)
Chronic exposure of various cell types to adrenergic agonists leads to a decrease
in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the
receptor away from the cell surface as well as a down-regulation ...
Chromosomal organization of adrenergic receptor genes.
(Proc Natl Acad Sci U S A, 1990-02)
The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are
a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors
that mediate the physiological effects of the hormone ...
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
(J Neurosci, 1992-10)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied
beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating
adenylyl cyclase activity. Beta ARK-mediated receptor ...
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.
(Proc Natl Acad Sci U S A, 1996-11-12)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled
receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and
desensitization of G protein-coupled receptors. ...
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
(Proc Natl Acad Sci U S A, 1991-10-01)
Light-dependent deactivation of rhodopsin as well as homologous desensitization of
beta-adrenergic receptors involves receptor phosphorylation that is mediated by the
highly specific protein kinases rhodopsin kinase (RK) ...