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Heptahelical receptor signaling: beyond the G protein paradigm. 

Hall, RA; Lefkowitz, Robert J; Premont, Richard Thomas (J Cell Biol, 1999-05-31)
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Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. 

Dolber, Paul Christian; Iaccarino, Guido; Koch, Walter J; Lefkowitz, Robert J (Hypertension, 1999-01)
Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1, which phosphorylates and desensitizes beta-adrenergic ...
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G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. 

Davies, MG; Fulton, Gregory J; Hagen, Per-Otto Frode; Huynh, Tam; Koch, Walter J; Lefkowitz, Robert J; Svendsen, E (Arterioscler Thromb Vasc Biol, 1998-08)
Vein grafting results in the development of intimal hyperplasia with accompanying changes in guanine nucleotide-binding (G) protein expression and function. Several serum mitogens that act through G protein-coupled receptors, ...
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Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissions. 

Cunningham, SH; Mairs, RJ; Wheldon, TE; Welsh, PC; Vaidyanathan, G; Zalutsky, MR (Br J Cancer, 1998-06)
Radiolabelled meta-iodobenzylguanidine (MIBG) is selectively taken up by tumours of neuroendocrine origin, where its cellular localization is believed to be cytoplasmic. The radiopharmaceutical [131I]MIBG is now widely used ...
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3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells. 

Vaidyanathan, G; Zhao, XG; Larsen, RH; Zalutsky, MR (Br J Cancer, 1997)
An analogue of meta-iodobenzylguanidine (MIBG) in which an aromatic hydrogen was replaced with fluorine has been found to possess many properties similar to those of the parent compound. Moreover, 4-fluoro-3-iodobenzylguanidine ...
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Adrenergic receptors. Models for regulation of signal transduction processes. 

Raymond, JR; Hnatowich, M; Lefkowitz, RJ; Caron, MG (Hypertension, 1990-02)
Adrenergic receptors are prototypic models for the study of the relations between structure and function of G protein-coupled receptors. Each receptor is encoded by a distinct gene. These receptors are integral membrane ...
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Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. 

Hausdorff, WP; Pitcher, JA; Luttrell, DK; Linder, ME; Kurose, H; Parsons, SJ; Caron, MG; ... (8 authors) (Proc Natl Acad Sci U S A, 1992-07-01)
A number of lines of evidence suggest that cross-talk exists between the cellular signal transduction pathways involving tyrosine phosphorylation catalyzed by members of the pp60c-src kinase family and those mediated by ...
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Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. 

Valiquette, M; Bonin, H; Hnatowich, M; Caron, MG; Lefkowitz, RJ; Bouvier, M (Proc Natl Acad Sci U S A, 1990-07)
Chronic exposure of various cell types to adrenergic agonists leads to a decrease in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the receptor away from the cell surface as well as a down-regulation ...
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Chromosomal organization of adrenergic receptor genes. 

Yang-Feng, TL; Xue, FY; Zhong, WW; Cotecchia, S; Frielle, T; Caron, MG; Lefkowitz, RJ; ... (8 authors) (Proc Natl Acad Sci U S A, 1990-02)
The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone ...
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The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. 

Arriza, JL; Dawson, TM; Simerly, RB; Martin, LJ; Caron, MG; Snyder, SH; Lefkowitz, RJ (J Neurosci, 1992-10)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating adenylyl cyclase activity. Beta ARK-mediated receptor ...
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AuthorLefkowitz, RJ (41)Koch, WJ (13)Caron, MG (11)Kelsoe, G (7)Rockman, HA (6)Pitcher, JA (5)Zalutsky, MR (5)Akhter, SA (4)Allen, LF (4)Bond, RA (4)... View MoreDate Issued1999 (11)1996 (9)1998 (9)1997 (6)1990 (5)1992 (5)1994 (5)1995 (5)1993 (4)1991 (3)TypeJournal article (61)Other article (1)SubjectAnimals (52)Humans (31)Mice (25)GTP-Binding Proteins (24)Molecular Sequence Data (20)Signal Transduction (18)beta-Adrenergic Receptor Kinases (17)Cyclic AMP-Dependent Protein Kinases (17)Receptors, Adrenergic, beta (15)Amino Acid Sequence (14)... View MoreAffiliation of Duke Author(s)Duke (62)
Duke Cancer Institute (62)
Institutes and Centers (62)
School of Medicine (62)
Basic Science Departments (56)Clinical Science Departments (51)Pathology (50)Biochemistry (46)Medicine (46)Chemistry (45)... View More
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