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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance. 

Han, S; Zheng, B; Dal Porto, J; Kelsoe, G (J Exp Med, 1995-12-01)
Germinal centers (GCs) are the sites of antigen-driven V(D)J gene hypermutation and selection necessary for the generation of high affinity memory B lymphocytes. Despite the antigen dependence of this reaction, injection ...
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New MIBG preparation to improve targeted radiotherapy and reduce toxic side-effects in neuroblastoma patients undergoing combination treatment. 

Mairs, RJ; Zalutsky, MR (Br J Cancer, 1995-07)
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G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. 

Touhara, K; Hawes, BE; van Biesen, T; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1995-09-26)
The mechanism of mitogen-activated protein (MAP) kinase activation by pertussis toxin-sensitive Gi-coupled receptors is known to involve the beta gamma subunits of heterotrimeric G proteins (G beta gamma), p21ras activation, ...
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The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. 

Pitcher, JA; Payne, ES; Csortos, C; DePaoli-Roach, AA; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1995-08-29)
Phosphorylation of G-protein-coupled receptors plays an important role in regulating their function. In this study the G-protein-coupled receptor phosphatase (GRP) capable of dephosphorylating G-protein-coupled receptor ...
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G proteins in medicine. 

Lefkowitz, RJ (N Engl J Med, 1995-01-19)

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AuthorLefkowitz, RJ (3)Csortos, C (1)Dal Porto, J (1)DePaoli-Roach, AA (1)Han, S (1)Hawes, BE (1)Kelsoe, G (1)Mairs, RJ (1)Payne, ES (1)Pitcher, JA (1)... View MoreDate Issued
1995 (5)
TypeJournal article (5)SubjectHumans (4)Animals (3)GTP-Binding Proteins (3)3-Iodobenzylguanidine (1)Adaptor Proteins, Signal Transducing (1)Adaptor Proteins, Vesicular Transport (1)Amino Acid Sequence (1)Androstadienes (1)Antibody Affinity (1)Antineoplastic Agents (1)... View MoreAffiliation of Duke Author(s)Duke (5)
Duke Cancer Institute (5)
Institutes and Centers (5)School of Medicine (5)Basic Science Departments (4)Clinical Science Departments (4)Pathology (4)Biochemistry (3)Chemistry (3)Medicine (3)... View More
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