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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.
(J Exp Med, 1995-12-01)
Germinal centers (GCs) are the sites of antigen-driven V(D)J gene hypermutation and
selection necessary for the generation of high affinity memory B lymphocytes. Despite
the antigen dependence of this reaction, injection ...
G proteins in medicine.
(N Engl J Med, 1995-01-19)
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
(Proc Natl Acad Sci U S A, 1995-08-29)
Phosphorylation of G-protein-coupled receptors plays an important role in regulating
their function. In this study the G-protein-coupled receptor phosphatase (GRP) capable
of dephosphorylating G-protein-coupled receptor ...
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
(Proc Natl Acad Sci U S A, 1995-09-26)
The mechanism of mitogen-activated protein (MAP) kinase activation by pertussis toxin-sensitive
Gi-coupled receptors is known to involve the beta gamma subunits of heterotrimeric
G proteins (G beta gamma), p21ras activation, ...