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T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.
(J Exp Med, 1996-09-01)
After immunization, activated splenic T cells proliferate in periarteriolar lymphoid
sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter
nascent germinal centers. Analysis of TCR V(D)J gene ...
Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
(J Clin Invest, 1996-04-01)
To assess the effect of targeted myocardial beta-adrenergic receptor (AR) stimulation
on relaxation and phospholamban regulation, we studied the physiological and biochemical
alterations associated with overexpression of ...
Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
(Br J Cancer, 1996-05)
The biodistribution of no-carrier-added (n.c.a.) meta-[131I]iodobenzylguanidine ([131I]MIBG)
and that prepared by the standard isotopic exchange method were compared in athymic
mice bearing SK-N-SH human neuroblastoma xenografts. ...
Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro.
(J Cell Biol, 1996-11)
In S. cerevisiae lacking SHR3, amino acid permeases specifically accumulate in membranes
of the endoplasmic reticulum (ER) and fail to be transported to the plasma membrane.
We examined the requirements of transport of the ...
Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.
(Proc Natl Acad Sci U S A, 1996-07-23)
Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases
(GRKs) constitute a family of serine/threonine kinases that play a major role in the
agonist-induced phosphorylation and desensitization ...
Mitogenic signaling via G protein-coupled receptors.
(Endocr Rev, 1996-12)
The third beta is not the charm.
(J Clin Invest, 1996-07-15)
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
(Proc Natl Acad Sci U S A, 1996-09-03)
Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled
receptor kinase-5 (GRK5), a serine/threonine kinase most abundantly expressed in the
heart compared with other tissues. Animals ...
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.
(Proc Natl Acad Sci U S A, 1996-11-12)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled
receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and
desensitization of G protein-coupled receptors. ...