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Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
(Circ Res, 1999-11-26)
Cardiac beta(2)-adrenergic receptor (beta(2)AR) overexpression is a potential contractile
therapy for heart failure. Cardiac contractility was elevated in mice overexpressing
beta(2)ARs (TG4s) with no adverse effects under ...
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
(J Clin Invest, 1999-07)
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic
strategy for treatment of cardiovascular diseases such as heart failure (HF). Before
gene therapy approaches to alter cardiac function ...
Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice.
(J Exp Med, 1999-08-02)
The role of apoptosis in affinity maturation was investigated by determining the affinity
of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific antibody-forming cells (AFCs) and
serum antibody in transgenic mice that overexpress ...
Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.
(J Cell Biol, 1999-01-25)
Reversible phosphorylation of nuclear proteins is required for both DNA replication
and entry into mitosis. Consequently, most cyclin-dependent kinase (Cdk)/cyclin complexes
are localized to the nucleus when active. Although ...
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
(Circ Res, 1999-01-08)
-Transgenic mouse models have been developed to manipulate beta-adrenergic receptor
(betaAR) signal transduction. Although several of these models have altered betaAR
subtypes, the specific functional sequelae of betaAR ...
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
(Hypertension, 1999-01)
Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic
receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1,
which phosphorylates and desensitizes beta-adrenergic ...
In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.
(Circulation, 1999-08-10)
BACKGROUND: The clinical syndrome of heart failure (HF) is characterized by an impaired
cardiac beta-adrenergic receptor (betaAR) system, which is critical in the regulation
of myocardial function. Expression of the betaAR ...
Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.
(Proc Natl Acad Sci U S A, 1999-03-30)
Restenosis continues to be a major problem limiting the effectiveness of revascularization
procedures. To date, the roles of heterotrimeric G proteins in the triggering of pathological
vascular smooth muscle (VSM) ...
Hetahelical receptor signaling: Beyond the G protein paradigm
(Journal of Cell Biology, 1999-05-31)