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Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
(Hypertension, 1999-01)
Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic
receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1,
which phosphorylates and desensitizes beta-adrenergic ...
G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.
(Arterioscler Thromb Vasc Biol, 1998-08)
Vein grafting results in the development of intimal hyperplasia with accompanying
changes in guanine nucleotide-binding (G) protein expression and function. Several
serum mitogens that act through G protein-coupled receptors, ...
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
(J Neurosci, 1992-10)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied
beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating
adenylyl cyclase activity. Beta ARK-mediated receptor ...
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.
(Proc Natl Acad Sci U S A, 1996-11-12)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled
receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and
desensitization of G protein-coupled receptors. ...
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
(Proc Natl Acad Sci U S A, 1991-10-01)
Light-dependent deactivation of rhodopsin as well as homologous desensitization of
beta-adrenergic receptors involves receptor phosphorylation that is mediated by the
highly specific protein kinases rhodopsin kinase (RK) ...
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
(Proc Natl Acad Sci U S A, 1998-06-09)
Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR)
function, which includes loss of betaAR density and functional uncoupling of remaining
receptors. An important mechanism for the ...
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
(Proc Natl Acad Sci U S A, 1996-09-03)
Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled
receptor kinase-5 (GRK5), a serine/threonine kinase most abundantly expressed in the
heart compared with other tissues. Animals ...
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
(Proc Natl Acad Sci U S A, 1997-10-28)
Cardiovascular gene therapy is a novel approach to the treatment of diseases such
as congestive heart failure (CHF). Gene transfer to the heart would allow for the
replacement of defective or missing cellular proteins that ...
Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.
(Proc Natl Acad Sci U S A, 1996-07-23)
Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases
(GRKs) constitute a family of serine/threonine kinases that play a major role in the
agonist-induced phosphorylation and desensitization ...
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
(Proc Natl Acad Sci U S A, 1998-11-24)
G protein-coupled receptor activation leads to the membrane recruitment and activation
of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their
inactivation. We have identified a novel ...