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Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. 

Dolber, Paul Christian; Iaccarino, Guido; Koch, Walter J; Lefkowitz, Robert J (Hypertension, 1999-01)
Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1, which phosphorylates and desensitizes beta-adrenergic ...
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G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. 

Davies, MG; Fulton, Gregory J; Hagen, Per-Otto Frode; Huynh, Tam; Koch, Walter J; Lefkowitz, Robert J; Svendsen, E (Arterioscler Thromb Vasc Biol, 1998-08)
Vein grafting results in the development of intimal hyperplasia with accompanying changes in guanine nucleotide-binding (G) protein expression and function. Several serum mitogens that act through G protein-coupled receptors, ...
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The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. 

Arriza, JL; Dawson, TM; Simerly, RB; Martin, LJ; Caron, MG; Snyder, SH; Lefkowitz, RJ (J Neurosci, 1992-10)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating adenylyl cyclase activity. Beta ARK-mediated receptor ...
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Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. 

Jaber, M; Koch, WJ; Rockman, H; Smith, B; Bond, RA; Sulik, KK; Ross, J; ... (10 authors) (Proc Natl Acad Sci U S A, 1996-11-12)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. ...
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The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. 

Lorenz, W; Inglese, J; Palczewski, K; Onorato, JJ; Caron, MG; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1991-10-01)
Light-dependent deactivation of rhodopsin as well as homologous desensitization of beta-adrenergic receptors involves receptor phosphorylation that is mediated by the highly specific protein kinases rhodopsin kinase (RK) ...
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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. 

Rockman, HA; Chien, KR; Choi, DJ; Iaccarino, G; Hunter, JJ; Ross, J; Lefkowitz, RJ; ... (8 authors) (Proc Natl Acad Sci U S A, 1998-06-09)
Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR density and functional uncoupling of remaining receptors. An important mechanism for the ...
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Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. 

Rockman, HA; Choi, DJ; Rahman, NU; Akhter, SA; Lefkowitz, RJ; Koch, WJ (Proc Natl Acad Sci U S A, 1996-09-03)
Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase-5 (GRK5), a serine/threonine kinase most abundantly expressed in the heart compared with other tissues. Animals ...
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Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. 

Akhter, SA; Skaer, CA; Kypson, AP; McDonald, PH; Peppel, KC; Glower, DD; Lefkowitz, RJ; ... (8 authors) (Proc Natl Acad Sci U S A, 1997-10-28)
Cardiovascular gene therapy is a novel approach to the treatment of diseases such as congestive heart failure (CHF). Gene transfer to the heart would allow for the replacement of defective or missing cellular proteins that ...
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Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 

Oppermann, M; Diversé-Pierluissi, M; Drazner, MH; Dyer, SL; Freedman, NJ; Peppel, KC; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1996-07-23)
Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization ...

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 

Premont, RT; Claing, A; Vitale, N; Freeman, JL; Pitcher, JA; Patton, WA; Moss, J; ... (9 authors) (Proc Natl Acad Sci U S A, 1998-11-24)
G protein-coupled receptor activation leads to the membrane recruitment and activation of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their inactivation. We have identified a novel ...
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AuthorLefkowitz, RJ (15)Koch, WJ (9)Akhter, SA (3)Caron, MG (3)Rockman, HA (3)Choi, DJ (2)Iaccarino, G (2)Inglese, J (2)Koch, Walter J (2)Lefkowitz, Robert J (2)... View MoreDate Issued1999 (4)1996 (3)1998 (3)1994 (2)1997 (2)1991 (1)1992 (1)1993 (1)TypeJournal article (17)SubjectAnimals (17)beta-Adrenergic Receptor Kinases (17)
Cyclic AMP-Dependent Protein Kinases (17)
GTP-Binding Proteins (10)Receptors, Adrenergic, beta (8)Signal Transduction (8)Mice (6)Rats (6)Isoproterenol (5)Kinetics (5)... View MoreAffiliation of Duke Author(s)Basic Science Departments (17)Biochemistry (17)Chemistry (17)Clinical Science Departments (17)Duke (17)
Duke Cancer Institute (17)
Institutes and Centers (17)Medicine (17)Medicine, Cardiology (17)Pathology (17)... View More
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