Now showing items 1-10 of 243
Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays.
(J Immunol Methods, 2014-07)
The External Quality Assurance Program Oversight Laboratory (EQAPOL) Flow Cytometry Program assesses the proficiency of NIH/NIAID/DAIDS-supported and potentially other interested research laboratories in performing Intracellular ...
Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays.
(J Immunol Methods, 2014-07)
Luminex bead array assays are widely used for rapid biomarker quantification due to the ability to measure up to 100 unique analytes in a single well of a 96-well plate. There has been, however, no comprehensive analysis ...
Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
(Mol Cell Biol, 2004-10)
beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between ...
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
(PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome ...
Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report.
(Emerging infectious diseases, 1998-04)
Well-documented cases of simultaneous human infection with more than one tick-borne pathogen are rare. To our knowledge only two dual infections have been reported: simultaneous human infection with the agent of ...
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of beta(2)-adrenergic receptors (beta(2)ARs) has been shown ...
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
(PLoS One, 2008-04-02)
BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...
Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
(PLoS Genet, 2010-04-29)
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of this enzyme are heritable traits, but major genetic determinants ...
Protocol for the "Implementation, adoption, and utility of family history in diverse care settings" study.
(Implement Sci, 2015-11-24)
BACKGROUND: Risk assessment with a thorough family health history is recommended by numerous organizations and is now a required component of the annual physical for Medicare beneficiaries under the Affordable Care Act. ...