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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells.
(J Clin Invest, 2015-02)
Satiety and other core physiological functions are modulated by sensory signals arising
from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors
called enteroendocrine cells. Despite being ...
Astrocytes refine cortical connectivity at dendritic spines.
(Elife, 2014-12-17)
During cortical synaptic development, thalamic axons must establish synaptic connections
despite the presence of the more abundant intracortical projections. How thalamocortical
synapses are formed and maintained in this ...
Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain.
(Mol Pain, 2015-04-10)
BACKGROUND: Mechanical and in particular tactile allodynia is a hallmark of chronic
pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based
neural tracing experiments and electrophysiology studies ...
Building an organic computing device with multiple interconnected brains.
(Scientific reports, 2015-07-09)
Recently, we proposed that Brainets, i.e. networks formed by multiple animal brains,
cooperating and exchanging information in real time through direct brain-to-brain
interfaces, could provide the core of a new type of computing ...
Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.
(Nat Neurosci, 2014-08)
Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating
nervous tissue, yet its mechanisms of effect are poorly understood. Here we report
new methods for studying the influence of TMS ...
Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish.
(Neurotoxicol Teratol, 2016-01)
Acute exposures to some individual polycyclic aromatic hydrocarbons (PAHs) and complex
PAH mixtures are known to cause cardiac malformations and edema in the developing
fish embryo. However, the heart is not the only organ ...
A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.
(Neuron, 2015-11-04)
The BDNF receptor tyrosine kinase, TrkB, underlies nervous system function in both
health and disease. Excessive activation of TrkB caused by status epilepticus promotes
development of temporal lobe epilepsy (TLE), revealing ...
Cloning of the cDNA for the human beta 1-adrenergic receptor.
(Proc Natl Acad Sci U S A, 1987-11)
Screening of a human placenta lambda gt11 library has led to the isolation of the
cDNA for the human beta 1-adrenergic receptor (beta 1AR). Used as the probe was the
human genomic clone termed G-21. This clone, which contains ...