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Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.
(PloS one, 2012-01)
It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic
encephalopathy (HIE). Many women use some form of analgesia during childbirth and
some anesthetic agents have been shown to be neuroprotective ...
A craniofacial-specific monosynaptic circuit enables heightened affective pain.
(Nature neuroscience, 2017-12)
Humans often rank craniofacial pain as more severe than body pain. Evidence suggests
that a stimulus of the same intensity induces stronger pain in the face than in the
body. However, the underlying neural circuitry for ...
TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.
(Nat Commun, 2014-09-02)
Animals need to sense and react to potentially dangerous environments. TRP ion channels
participate in nociception, presumably via Ca(2+) influx, in most animal species.
However, the relationship between ion permeation and ...
A whole-cell and single-channel study of the voltage-dependent outward potassium current in avian hepatocytes.
(J Gen Physiol, 1988-02)
Voltage-dependent membrane currents were studied in dissociated hepatocytes from chick,
using the patch-clamp technique. All cells had voltage-dependent outward K+ currents;
in 10% of the cells, a fast, transient, ...
Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.
(PLoS One, 2014)
Female sex is associated with improved outcome in experimental brain injury models,
such as traumatic brain injury, ischemic stroke, and intracerebral hemorrhage. This
implies female gonadal steroids may be neuroprotective. ...
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis.
(Arthritis Res Ther, 2012-04-17)
INTRODUCTION: Osteoarthritis (OA) results in pain and disability; however, preclinical
OA models often focus on joint-level changes. Gait analysis is one method used to
evaluate both preclinical OA models and OA patients. ...
Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
(J Biol Chem, 2016-05-06)
TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory
neurons; however, the contribution of the channel in either cell to neurosensory function
remains to be elucidated. We recently reported TRPV4 ...
ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat.
(J Cell Biol, 2002-10-14)
The role of GTPase-activating protein (GAP) that deactivates ADP-ribosylation factor
1 (ARF1) during the formation of coat protein I (COPI) vesicles has been unclear.
GAP is originally thought to antagonize vesicle formation ...
Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.
(Gut, 2016-04)
OBJECTIVE: The ductular reaction (DR) involves mobilisation of reactive-appearing
duct-like cells (RDC) along canals of Hering, and myofibroblastic (MF) differentiation
of hepatic stellate cells (HSC) in the space of Disse. ...